ADH5


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ADH5

A gene on chromosome 4q23 that encodes a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. ADH5 has minimal activity for ethanol oxidation, but has a high activity for oxidation of long-chain aliphatic alcohols and oxidation of S-(hydroxymethyl) glutathione. The ADH5 protein product is critical in metabolic elimination of formaldehyde, a potent irritant and sensitising agent that causes lacrymation, rhinitis, pharyngitis and contact dermatitis.
References in periodicals archive ?
ADH5 is a cocktail of IHC markers that includes CK8/18-pink, CK5/14-brown, and p63-brown (hematoxylin-eosin, original magnifications x40 [A, E, and I], x100 [B], X200 [G], and x400 [J]; CK5, original magnifications X200 [C] and x100 [K]; p63, original magnifications X200 [D] and x100 [L]; ADH5, original magnifications x40 [F] and X200 [H]).
0 20 III ADH5 ADH5 [chi] >1,000 100 IV ADH7 ADH7 [sigma]([mu]) 30.
For example, several studies found other variations in and near the ADH1B gene, as well as in or near the ADH4, ADH1C, ADH5, ADH6, and ADH7 genes that affect risk for alcoholism or the level of alcohol consumption (see the article by Hurley and Edenberg, pp.
The product of the ubiquitously expressed ADH5 gene is the glutathione-dependent formaldehyde dehydrogenase (also known as nitrosoglutathione reductase [GSNOR]).