ADH1A

A gene on chromosome 4q21-23 that encodes class-I alcohol dehydrogenase, alpha subunit, a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. The encoded protein plays a major role in ethanol catabolism and is highly expressed in adults livers.

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aldehyde reductase

References in periodicals archive ?

The variation in alcohol elimination and the oxidation of acetaldehyde, genetically determined alcohol dehydrogenase 1-3 (before named ADH1A, ADH1B and ADH1C) and aldehyde dehydrogenase (ALDH2) plays a major role in the pathogenesis of the clinical syndrome.

Characterization of polymorphisms of genes ADH2, ADH3, ALDH2 and CYP2E1 and relationship to the alcoholism in a Colombian population/Caracterizacion de polimorfismos de los genes ADH2, ADH3, ALDH2 y CYP2E1 y su relacion con el alcoholismo en una poblacion colombiana

Luo and colleagues [15-22] reported that the diplotypes at ADH1A, 1B, 1C, 4 and 7, CHRM2, OPRM1, OPRD1 and OPRK1 were much more strongly associated with alcohol dependence, drug dependence and personality factors than the alleles, genotypes and haplotypes at these sites.

Use of diplotypes--matched haplotype pairs from homologous chromosomes--in gene-disease association studies

2006) and modest evidence of association with noncoding SNPs (5) in ADH1A and ADH1B.

Genetic research: who is at risk for alcoholism?

ADH1A contains either two alpha subunits or one alpha plus one beta or gamma subunit.

Pharmacogenomics and its applications

Of these, the ADH1A, ADH IB, and ADH 1C genes encode the majority of the ADH enzymes that metabolize alcohol in the liver.

Biology, genetics, and environment: underlying factors influencing alcohol metabolism

One important group of ADH enzymes are the ADH class I isozymes ADH1A, ADH1B, and ADH1C.

The genetics of alcohol and other drug dependence

The ADH1A, ADH1B, and ADH1C genes (1) produce closely related proteins that function as homo- and heterodimers (Hurley et al.

Genes encoding enzymes involved in ethanol metabolism

Humans have seven different genes, called ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, and ADH7, that encode medium-chain ADHs (see Table 1).

The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants

The ADH1A, ADH1B, and ADH1C genes1 produce closely related proteins that function as homo- and heterodimers (Hurley et al.

Genes encoding enzymes involved in ethanol metabolism

There are three types of ADH1: ADH1A, ADH1B, and ADH1C.

Variations in ADH and ALDH in Southwest California Indians

The class I ADH enzymes include ADH1A, ADH1B, and ADH1C, which are considered the most important ADH isoforms in alcohol metabolism because they are present in the largest amounts and account for the majority of alcohol metabolism in humans (Jornvall and Hoog 1995).

These are three isozymes known as alpha ([alpha]), beta ([beta]), and gamma ([gamma]), which are encoded by the ADH1A, ADH1B, and ADH1C genes, respectively.