ADH1A

ADH1A

A gene on chromosome 4q21-23 that encodes class-I alcohol dehydrogenase, alpha subunit, a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. The encoded protein plays a major role in ethanol catabolism and is highly expressed in adults livers.
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GATA-2 and HNF-3beta regulate the human alcohol dehydrogenase 1A (ADH1A) gene.
Ecological niche difference associated with varied ethanol tolerance between Drosophila suzukii and Drosophila melanogaster (Diptera: Drosophilidae)
Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Alcohol's effects on the brain: Neuroimaging results in humans and animal models
The variation in alcohol elimination and the oxidation of acetaldehyde, genetically determined alcohol dehydrogenase 1-3 (before named ADH1A, ADH1B and ADH1C) and aldehyde dehydrogenase (ALDH2) plays a major role in the pathogenesis of the clinical syndrome.
Characterization of polymorphisms of genes ADH2, ADH3, ALDH2 and CYP2E1 and relationship to the alcoholism in a Colombian population/Caracterizacion de polimorfismos de los genes ADH2, ADH3, ALDH2 y CYP2E1 y su relacion con el alcoholismo en una poblacion colombiana
Luo and colleagues [15-22] reported that the diplotypes at ADH1A, 1B, 1C, 4 and 7, CHRM2, OPRM1, OPRD1 and OPRK1 were much more strongly associated with alcohol dependence, drug dependence and personality factors than the alleles, genotypes and haplotypes at these sites.
Use of diplotypes--matched haplotype pairs from homologous chromosomes--in gene-disease association studies
2006) and modest evidence of association with noncoding SNPs (5) in ADH1A and ADH1B.
Genetic research: who is at risk for alcoholism?
The subunits are encoded by six different genetic loci (ADH1A, ADH1B*1, ADH1C*1, and ADH4-ADH7--formerly ADH1 through ADH7, respectively).
Pharmacogenomics and its applications
Of these, the ADH1A, ADH IB, and ADH 1C genes encode the majority of the ADH enzymes that metabolize alcohol in the liver.
Biology, genetics, and environment: underlying factors influencing alcohol metabolism
One important group of ADH enzymes are the ADH class I isozymes ADH1A, ADH1B, and ADH1C.
The genetics of alcohol and other drug dependence
* The ADH1A, ADH1B, and ADH1C genes (1) produce closely related proteins that function as homo- and heterodimers (Hurley et al.
Genes encoding enzymes involved in ethanol metabolism
Humans have seven different genes, called ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, and ADH7, that encode medium-chain ADHs (see Table 1).
The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants
* The ADH1A, ADH1B, and ADH1C genes1 produce closely related proteins that function as homo- and heterodimers (Hurley et al.
Genes encoding enzymes involved in ethanol metabolism
There are three types of ADH1: ADH1A, ADH1B, and ADH1C.
Variations in ADH and ALDH in Southwest California Indians

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