ADH1A

ADH1A

A gene on chromosome 4q21-23 that encodes class-I alcohol dehydrogenase, alpha subunit, a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. The encoded protein plays a major role in ethanol catabolism and is highly expressed in adults livers.
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The ADH1A, ADH1B, and ADH1C genes (1) produce closely related proteins that function as homo- and heterodimers (Hurley et al.
Moreover, noncoding SNPs in the region of ADH1A, ADH1B, and ADH1C have been associated with alcoholism and drinking phenotypes, as have SNPs in ADH7 and ADH5.
For example, a commonly used approach to identify individual problems--that is, the use of specific antibodies--has not yet worked with the ADH1A, ADH1B, and ADH1C proteins because these proteins are highly conserved, with their sequence at the protein level more than 93 percent identical; moreover, many of the sequence changes are located within functional sites and not optimally situated for antibody recognition.
2006) and modest evidence of association with noncoding SNPs (5) in ADH1A and ADH1B.
ADH1A contains either two alpha subunits or one alpha plus one beta or gamma subunit.
One important group of ADH enzymes are the ADH class I isozymes ADH1A, ADH1B, and ADH1C.
Humans have seven different genes, called ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, and ADH7, that encode medium-chain ADHs (see Table 1).
Noncoding SNPs in the ADH1A and ADH1B genes also appear to be associated with alcoholism risk in the European-American family sample (Edenberg et al.
Table 1 Alcohol Dehydrogenase (ADH) Genes and Proteins Official Gene Nonstandard Name* Old Name ([dagger]) Name ([double dagger]) ADH1A ADH1 ADH1A ADH1B ADH2 ADH1B ADH1C ADH3 ADH1C ADH4 ADH4 ADH2 ADH5 ADH5 ADH3 ADH6 ADH6 ADH5 ADH7 ADH7 ADH4 Official Gene Name* Sequence ([section]) Protein Class ([paragraph]) ADH1A NM_000667 [alpha] I ADH1B NM_000668 [beta] I ADH1C NM_000669 [gamma] I ADH4 NM_000670 [pi] II ADH5 NM_000671 [chi] III ADH6 NM_000672 ADH6 V ADH7 NM_000673 [sigma] IV *Gene symbol approved by the Human Genome Organization (HUGO) Gene Nomenclature Committee (www.
There are three types of ADH1: ADH1A, ADH1B, and ADH1C.
The class I ADH enzymes include ADH1A, ADH1B, and ADH1C, which are considered the most important ADH isoforms in alcohol metabolism because they are present in the largest amounts and account for the majority of alcohol metabolism in humans (Jornvall and Hoog 1995).
These are three isozymes known as alpha ([alpha]), beta ([beta]), and gamma ([gamma]), which are encoded by the ADH1A, ADH1B, and ADH1C genes, respectively.