GATA-2 and HNF-3beta regulate the human alcohol dehydrogenase 1A (
ADH1A) gene.
Genetic variation in alcohol dehydrogenase (
ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
The variation in alcohol elimination and the oxidation of acetaldehyde, genetically determined alcohol dehydrogenase 1-3 (before named
ADH1A, ADH1B and ADH1C) and aldehyde dehydrogenase (ALDH2) plays a major role in the pathogenesis of the clinical syndrome.
Luo and colleagues [15-22] reported that the diplotypes at
ADH1A, 1B, 1C, 4 and 7, CHRM2, OPRM1, OPRD1 and OPRK1 were much more strongly associated with alcohol dependence, drug dependence and personality factors than the alleles, genotypes and haplotypes at these sites.
2006) and modest evidence of association with noncoding SNPs (5) in
ADH1A and ADH1B.
The subunits are encoded by six different genetic loci (
ADH1A, ADH1B*1, ADH1C*1, and ADH4-ADH7--formerly ADH1 through ADH7, respectively).
Of these, the
ADH1A, ADH IB, and ADH 1C genes encode the majority of the ADH enzymes that metabolize alcohol in the liver.
One important group of ADH enzymes are the ADH class I isozymes
ADH1A, ADH1B, and ADH1C.
* The
ADH1A, ADH1B, and ADH1C genes (1) produce closely related proteins that function as homo- and heterodimers (Hurley et al.
Humans have seven different genes, called
ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, and ADH7, that encode medium-chain ADHs (see Table 1).
* The
ADH1A, ADH1B, and ADH1C genes1 produce closely related proteins that function as homo- and heterodimers (Hurley et al.
There are three types of ADH1:
ADH1A, ADH1B, and ADH1C.