ADH1A

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ADH1A

A gene on chromosome 4q21-23 that encodes class-I alcohol dehydrogenase, alpha subunit, a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. The encoded protein plays a major role in ethanol catabolism and is highly expressed in adults livers.
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The ADH1 C*1 allele varies substantially across different populations.
In the ADH1 treatment, diameter values fluctuated between limits of 9.65% (Gta Dur) and 136.7% (Waha).
Based on the early research finding that retinol was oxidized to retinaldehyde by the enzyme similar to ADH1 [6], retinaldehyde was oxidized to retinoic acid by aldehyde dehydrogenase 1 (ALDH1) [13].
Caption: Gel profile of yeast isolates generated using ADH1 primer Lane 1: YFN, 2: YMO, 3: YMM, 4: YYPO, 5: YGP, 6: YSJ, 7: YPA, 8: YWM, 9: YAP, 10: YBA, L-Ladder.
Linkage disequilibrium and sequence diversity in a 500-kbp region around the adh1 locus in elite maize germplasm.
The high-dose tissues demonstrated typical PPAR[alpha]-mediated responses associated with [beta]-oxidation of fats, metabolism of bile acids and steroids, and early cell proliferation [e.g., HCD, 3-ketoacyl-CoA thiolase A + B (3KCTA+B), ACOX, aldehyde dehydrogenase 1 (ADH1), and CYP4A1].
Mutants on CLGs 6 and 8 could be associated with yield or seed weight quantitative trait loci (QTL) (Mansur et al., 1993; Orf et al., 1999), and Adh1 could be associated with flooding tolerance QTL (VanToai et al., 2001).
The ADH1, ADH2, and ADH3 genes encode the class I enzymes [alpha], [beta], and [gamma], respectively.
Our findings show that the expression level of ethanol producing enzyme, alcohol dehydrogenase I (ADH1) was increased upon treatment of cells with UV radiation and screening in the presence of furfural (Table 1 and Fig.
* Acetylation of H3K9 also is associated with increased ADH1 expression in cultured rat hepatocytes treated with 100 mM ethanol for 24 hours, suggesting that ethanol (and its metabolites) may amplify ethanol metabolism (Park et al.
Furthermore, polymorphisms exist for several of the genes encoding ADH enzymes, the best known of which occur in the genes encoding ADH1. There are three types of ADH1: ADH1A, ADH1B, and ADH1C.
In two relatively large regions of the maize genome, a 225-kb section containing the adh1 gene (Tikhonov et al., 1999) and a 78-kb segment containing a zein gene cluster (Llaca and Messing, 1998), genic regions were found to be interspersed among large blocks of repetitive DNA.