Alcohol Flush Reaction

(redirected from ADH deficiency)
A condition caused by the incomplete metabolism of alcohol with accumulation of acetaldehyde due to a missense polymorphism in acetaldehyde dehydrogenase—ALDH2—resulting in bright red skin due to capillary dilation of face, neck, shoulder, and sometimes the entire body after consuming alcohol. Those with ALDH2 deficiency have up to a 10-fold greater risk of oesophageal cancer, attributed to the accumulation of acetaldehyde
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In patients with severe ADH deficiency urine osmolality prior to ADH administration was much less than plasma osmolality after it when the urine osmolality was increased by more than 50% [8].
ADH deficiency develops only after extensive destruction of the hypothalamic neurosecretory cells [11].
Diabetes insipidus (DI) is an ADH deficiency disorder of the hypothalamus.
[8] With complete ADH deficiency, urine output may approach 1 L/hour.
Characteristics of ADH deficiency include diabetes insipidus, dehydration, polyuria, polydypsia, and increased serum osmolality (Shimon & Melmed, 1998).