ADCC


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cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.

ADCC

ADCC

antibody-dependent cell-mediated cytotoxicity.

ADCC

abbreviation for antibody-dependent cell-mediated cytotoxicity.

ADCC

antibody-dependent cell-mediated cytotoxicity.
References in periodicals archive ?
The group at the University of Melbourne's Department of Microbiology and Immunology analysed blood samples of people with HIV and found their virus had evolved to evade or 'escape' the ADCC antibodies against HIV they are making to try to control their virus.
The group is now working on designing HIV vaccines to induce ADCC antibodies that make it more difficult for the virus to escape.
However, the ADCC was adamant that the day was to be as solemn as Good Friday when no cinemas, hotels, racecourses or other sporting venues would be open.
We called up a committee meeting and arrived at the conclusion that the next best team will play UBL," said Wajahat Husain, president of ADCC who is also the president and CEO of the bank.
All participating teams shall be provided coloured clothing and match balls by the ADCC.
XmAb engineered high ADCC Fc domains have an improved capacity to recruit the immune system to target cancer cells, giving antibodies more tumor killing power.
Research shows that POTELLIGENT([R]) Technology dramatically enhances ADCC activity of an antibody in vitro, and significantly increases potency and efficacy of the antibody in vivo.
Also present on the occasion were Sudhir Kumar Shetty, COO of UAE Exchange Centre, David East, CEO of Abu Dhabi Cricket Club and Emirates Cricket Board and Wajahat Hussain, president of ADCC.
The Queensland Government is proud to support the ADCC s fundraising efforts by launching the 2013 ANZAC Appeal and donating $15,000 to launch the appeal.
XmAb engineered high ADCC Fc domains give antibodies more tumor killing power by improving their capacity to recruit the immune system to target cancer cells.
We believe this represents an important opportunity to promote the development of more effective targeted treatments for debilitating diseases where enhanced ADCC might offer a significant therapeutic benefit.
XmAb[R] engineered high ADCC Fc domains give antibodies more tumor killing power by improving their capacity to recruit the immune system to target cancer cells, a process called antibody-dependent cell cytotoxicity or ADCC.