ADCC


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cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.

ADCC

References in periodicals archive ?
Adenoid cystic carcinoma (AdCC) accounts for approximately 10% of all malignant salivary gland tumors.
These features are useful in limiting the differential diagnosis and are especially good at separating MASC from the primary morphologic mimickers of AciCC and adenocarcinoma, not otherwise specified; however, other salivary gland tumors, such as PLGA and AdCC, can show a similar immunophenotype.
Stable clones were isolated and characterized for ADCC activity using the iLite effector cells and cetuximab (Erbitux[TM], Merck Serono, France) giving rise to the [EGFR.sup.+] target cell line.
Twenty five percent AdCC arise in the parotid gland and 60% from the minor salivary glands15 with palate as its most frequent site.16 Adenoid cystic carcinoma shows peak incidence in 4th to 7th decades of life.20 Treatment for AdCC is surgery followed by radiotherapy.19
AdCC is important because it is relentless clinical course and usually a fatal outcome.
Given observed kinetics of CD16+ cell depletion and recovery following administration of the mAb, what is the optimal schedule to optimize ADCC?
Fighting spirit: Braulio Estima can't hide his emotions after beating Jacare Souza (below) to lift the ADCC world crown.
"These results show what a slippery customer the HIV virus is, but also shows that these ADCC antibodies are really forcing the virus into changing, in ways that cause it to be weaker," he said.
AccretaMab(TM) platform consists of POTELLIGENT(R) and COMPLEGENT(TM) Technologies, creating a superior antibody molecule with enhanced ADCC and CDC activities.
ADCC Lawson pointed out that the Highway Code states drivers should not smoke and drive as it causes a distraction.
Preclinice I in-vitro studies showed that this second-generation nonfucosylated anti-CD30 antibody demonstrated enhanced ADCC (antibody-dependent cellular cytotoxicity), an important mechanism of action of therapeutic antibodies, and was active in inhibiting tumour growth in in-vivo xenograft models.
HuMax-ZP3 potently exhibits the Antibody-Dependent Cellular Cytotoxicity (ADCC) and Complement Dependent Cytotoxicity (CDC) immune system killing mechanisms against ZP3-expressing tumor cells, Genmab said.