ADCC


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cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.

ADCC

ADCC

antibody-dependent cell-mediated cytotoxicity.

ADCC

abbreviation for antibody-dependent cell-mediated cytotoxicity.

ADCC

antibody-dependent cell-mediated cytotoxicity.
References in periodicals archive ?
That comparison testing demonstrated that, regardless of the variant used, the Promega ADCC RGA was capable of differentiating potencies of the source 3 mAb from source 2, and, although the relative potencies were greater between source 2 and the two products than the source 2 product tested against itself, the results con| firmed the much closer response similarity between the source 1 and 2 mAbs (Table 2).
The group at the University of Melbourne's Department of Microbiology and Immunology analysed blood samples of people with HIV and found their virus had evolved to evade or 'escape' the ADCC antibodies against HIV they are making to try to control their virus.
The group is now working on designing HIV vaccines to induce ADCC antibodies that make it more difficult for the virus to escape.
The ADCC, although remarkably inter-denominational, seemed content with Garland's characterisation of the day as `Australia's All Soul's Day', the day on which Catholic Europe commemorated all the departed, obviously with a Requiem Mass.
Following extensive in-house studies and a successful alpha trial program, the ADCC Reporter Bioassay is now being adopted by global biologics companies as well as being offered as a service by Charles River Laboratories.
The GlymaxX technology substantially improves the ADCC activity of one of our lead bispecific antibodies for the treatment of solid tumors so that it further enhances the tumor cell killing capacity of an already very potent molecule," said Mark Throsby, chief scientific officer of Merus B.
We are pleased to have formed this alliance with ADCC as it brings a wealth of benefits to our owners in Abu Dhabi," commended Kamal Rafih, general manager of EMC and Western Motors.
It is based on an active modulation of antibody glycosylation during production leading to antibody products with increased ADCC (antibody-dependent cellular cytotoxicity).
Patent 7,931,895 titled "Monoclonal Antibodies with Enhanced ADCC Function" on April 26, 2011, by the U.
The Queensland Government has committed $180,000 in sponsorship to the ADCC between 2016 and 2018, to support the staging of the Students ANZAC Commemoration Ceremony and ANZAC Dawn Services.
The opener smashed 125 not out in his team's 186 for two in reply to Ferco Group's 185 for seven at the ADCC grounds over the weekend.
The Potelligent technology is intended to enhance the potency and efficacy of therapeutic antibodies by improving ADCC, which is one of the main mechanisms of therapeutic antibodies.