ADAS-Cog


Also found in: Acronyms.

ADAS-Cog

An 11-part neurological testing instrument used to assess patients with Alzheimer’s disease. ADAS-Cog is used as a primary outcome measure in many drug trials, and regarded as the best brief exam for assessing language and memory skills.

Time required
30 minutes.

Pros
More thorough than Blessed or MMSE.
References in periodicals archive ?
In the 10-patient analysis, ADAS-cog scores improved by an average of 4.
In order to compare changes over time for MMSE, ADAS-Cog, and ADL scores between the two patient groups: those receiving ChEIs alone and those treated by the combination ChEIs and Gb, linear mixed effect models with random intercept and random slope were used to take into account the heterogeneity of baseline scores and individual slopes over time.
Severidad de demencia en 37 casos de Enfermedad de Alzheimer segun el aspecto cognitivo evaluado por ADAS-cog (18).
The investigators measured items such as memory, word recall and recognition, orientation and comprehension of spoken language (using the ADAS-Cog Scale); and developed an overall picture of the patient's deterioration or improvement, based on interviews with both patients and their caregivers (using the CIBIC-Plus Scale).
This indicates that a full neuropsychological evaluation, rather than sole use of a global screening measure such as the MMSE [Mini-Mental State Exam] or ADAS-cog [Alzheimer's Disease Assessment Scale-Cognitive] may be useful for predicting future cognitive decline.
The researchers observed some deterioration over time based on the ADAS-Cog and other neuropsychological measures.
This study showed that adjunctive therapy with Lu AE58054 (plus 10 mg/day donepezil) at the selected dose resulted in statistically significant improvement in cognitive performance, as measured by the ADAS-cog (Alzheimer's Disease Assessment Scale-cognitive sub-scale) over a 24 week treatment period versus placebo (plus 10mg/day donepezil).
12) To test for episodic memory, 10-minute delayed recall of a word list from the ADAS-Cog was used.