NUP98

(redirected from ADAR2)

NUP98

A gene on chromosome 11p15.5 that encodes a nucleoporin (one of the estimated 50 nucleoporins), which derives from cleavage of a 186-kDa precursor and functions as one of several docking site nucleoporins of transport substrates.

Molecular pathology
NUP98 fuses to several genes after chromosome translocations in acute myeloid leukaemia (AML) and T-cell acute lymphocytic leukaemia (T-ALL), and is one of several genes located in the imprinted gene domain of 11p15.5, a tumour-suppressor gene region. Alterations in 11p15.5 region are associated with the Beckwith-Wiedemann syndrome, Wilms tumour, rhabdomyosarcoma and adrenocortical carcinoma, as well as lung, ovarian and breast cancers.
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References in periodicals archive ?
Specifically, the research team discovered that proteins ADAR1 and ADAR2, which are involved in the editing of RNA, could potentially be used as a biomarkers to detect disorder leading to gastric cancer.
Our team is the first to conduct a comprehensive analysis demonstrating that changes in RNA sequences, which are caused by the differentially expressed RNA editing enzymes ADAR1 and ADAR2 in gastric tumours, may serve as a novel driving force for gastric cancer, said Asst Prof Chen.
ADAR1 and ADAR2 are two upstream regulators fine-tuning the editing of RNAs and have opposing effects on gastric cancer development.
21) Se ha observado activacion diferencial de las adenosindeaminasas dependientes de RNA (ADAR1, ADAR2 y RED2) en plasticidad sinaptica e isquemia, (22) especificamente se observa activacion de ADAR2 en isquemia, situacion que explica la regulacion de GluR2 y consecuente vulnerabilidad a esta noxa.