ADAMTSaj9

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ADAMTSaj9

An ADAMTSs family enzyme encoded by ADAMTS9 on chromosome 3p14.1, which was first isolated from human brain. It is expressed in ovary, pancreas, heart, lung, placenta, and kidney, and strongly so in fetal tissues. It is downregulated or absent in nasopharyngeal carcinoma (NPC), especially in aggressive cases and/or with nodal metastases. Upregulation of ADAMTS9 reduces colony-forming ability of NPC in vitro, supporting the belief that ADAMTS9 is a tumour suppressor gene.
References in periodicals archive ?
Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.
Yaykasli et al., "Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-kB signaling pathways in human chondrocytes," Cell Biology International, vol.
ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes.