ADAMTSah7

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ADAMTSah7

An ADAMTSs family enzyme encoded by ADAMTS7 on chromosome 15q24.2 which is widely expressed in human brain, heart, lung, liver, pancreas, kidney, skeletal muscle, and placenta and thought to play a role in COMP degradation
References in periodicals archive ?
We also examined the expression levels of ADAMTS-1, ADAMTS-2, ADAMTS-7, and ADAMTS-15, but they were not expressed at detectable levels in both control and preeclamptic placentas (data not shown).
Lu et al., "ADAMTS-7 expression increases in the early stage of angiotensin II-induced renal injury in elderly mice," Kidney & Blood Pressure Research, vol.
The ADAMTS proteins are involved in many different processes, such as proteolysis of proteoglycans (ADAMTS-1, 4, 5, 8, and 9) or degradation of cartilage oligomeric matrix protein (ADAMTS-7 and 12).
[42], who reported that miR-29b-3p inhibits vascular smooth muscle cell calcification by decreasing the target genes dis-integrin and metalloproteinase with thrombospondin motif-7 (ADAMTS-7) expression, in an inorganic phosphorus and chronic kidney disease-induced rat calcification model.
Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation.
Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during degeneration of rat caudal intervetebral disc.
The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.
Liu, "Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein," Arthritis and Rheumatism, vol.
ADAMTS-17 and -19, ADAMTS-16 and -18, ADAMTS-7 and -12, and ADAMTS-6 and -10 compose the structurally related ADAMTS pairs division.
Additionally, PTHLH and both of its targets, ADAMTS-7 and -12, were downregulated in the fibroblasts of BDE patients.
In addition, ADAMTS-7 and -12 were colocalized with COMP both in the cytoplasm and on the surface of human chondrocytes [25, 35].
It was reported that alpha-2-macroglobulin ([[alpha].sub.2] M) acted as a substrate for both ADAMTS-7 and ADAMTS-12 and efficiently protected COMP degradation by these enzymes by in vitro digestion assays [43].