We also examined the expression levels of ADAMTS-1, ADAMTS-2, ADAMTS-7
, and ADAMTS-15, but they were not expressed at detectable levels in both control and preeclamptic placentas (data not shown).
Lu et al., "ADAMTS-7
expression increases in the early stage of angiotensin II-induced renal injury in elderly mice," Kidney & Blood Pressure Research, vol.
The ADAMTS proteins are involved in many different processes, such as proteolysis of proteoglycans (ADAMTS-1, 4, 5, 8, and 9) or degradation of cartilage oligomeric matrix protein (ADAMTS-7
, who reported that miR-29b-3p inhibits vascular smooth muscle cell calcification by decreasing the target genes dis-integrin and metalloproteinase with thrombospondin motif-7 (ADAMTS-7
) expression, in an inorganic phosphorus and chronic kidney disease-induced rat calcification model.
Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation.
Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during degeneration of rat caudal intervetebral disc.
The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.
Liu, "Granulin-epithelin precursor binds directly to ADAMTS-7
and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein," Arthritis and Rheumatism, vol.
ADAMTS-17 and -19, ADAMTS-16 and -18, ADAMTS-7 and -12, and ADAMTS-6 and -10 compose the structurally related ADAMTS pairs division.
Additionally, PTHLH and both of its targets, ADAMTS-7 and -12, were downregulated in the fibroblasts of BDE patients.
In addition, ADAMTS-7 and -12 were colocalized with COMP both in the cytoplasm and on the surface of human chondrocytes [25, 35].
It was reported that alpha-2-macroglobulin ([[alpha].sub.2] M) acted as a substrate for both ADAMTS-7 and ADAMTS-12 and efficiently protected COMP degradation by these enzymes by in vitro digestion assays .