ADAMTSaf5

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ADAMTSaf5

An ADAMTSs family enzyme encoded by ADAMTS5 on chromosome 21q21.3 which, like ADAMTS4, cleaves aggrecan, the major proteoglycan of cartilage. It is highly expressed in placenta and appears to play a role in proteolytic processing during the peri-implantation period. It may be upregulated in arthritic diseases.
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Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis.
Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis
The breakdown of AGC is believed to be initiated by a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and ADAMTS-5.[1]
Effect of Mechanical Stress in Combination with Verapamil on Levels of Aggrecan and ADAMTS-5 mRNAs and Proteins in Human Osteoarthritic Chondrocyte/Agarose Constructs
Brevican is also degraded by various MMPs and ADAMTS proteases [56, 57], including ADAMTS-4 [58] and ADAMTS-5 [59].
Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics
Small Molecules to Inhibit ADAMTS-5 for Osteoarthritis 31
Asahi Kasei Pharma Corp. - Product Pipeline Review -- 2015 Is Released
Shi, "Expression of ADAMTs-5 and TIMP-3 in the condylar cartilage of rats induced by experimentally created osteoarthritis," Archives of Oral Biology, vol.
Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis
In the EGCG-treated (intraperitoneal injection) mice, articular cartilage shows downregulation of MMP-1, MMP-3, MMP-8, MMP-13, ADAMTS-5, IL-1[beta], and TNF[alpha] mRNA and upregulation of CBP/p300 interacting transactivator with ED-rich tail 2 (CITED2), which suppresses MMPs transcription [31].
Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis
The expression levels of MMP-1, MMP-3, MMP13, ADAMTS-4, ADAMTS-5, collagen type II alpha 1 chain (COL2A1), cartilage oligomeric matrix protein (COMP), collagen type I alpha 2 chain (COL1A2), and collagen type X alpha 1 chain (COL10A1) mRNA in the articular cartilage were determined by RT-PCR assays using a SYBR green kit (Sigma-Aldrich) according to the method described by Takahito [21] and Hyuck [22].
Interleukin-17 Can Induce Osteoarthritis in Rabbit Knee Joints Similar to Hulth's Method
After 24 hrs of stimulation with DAMPs, culture media were dialyzed and concentrated for examination of MMP-1, MMP-3, MMP-13, ADAMTS-5, and ADAM-8.
DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone
The primary antibodies included rabbit polyclonal antibodies specific for ADAMTS-1 (1:50; Abcam, Cambridge, United Kingdom), ADAMTS-4 (1:50; AVIVA Systems Biology, San Diego, California), ADAMTS-5 (1:100; Novus, Littleton, Colorado), ADAMTS-14 (1:100, Abcam), and rabbit polyclonal IgG purified from preimmune serum samples (1:50 or 1:100, ab27478; Abcam).
Differential Expression Patterns of a Disintegrin and Metalloproteinase With Thrombospondin Motifs (ADAMTS) -1, -4, -5, and -14 in Human Placenta and Gestational Trophoblastic Diseases
During the OA process, aggrecans are cleaved at specific Glu-Xaa peptide bonds by aggrecanases such as ADAMTS-4 and ADAMTS-5, resulting in a breakdown of HA and link proteins and a decrease in stable ternary complexes in the extracellular matrix [9].
Articular cartilage gene expression after coxofemoral joint luxation in the dog
Results: We report that low mass 4.5-kDa HA-fs enhance MMPs, including MMP -3 and 13 but not an ADAMTS-5 in chondrocytes and cartilage explant cultures, to a lesser extent than a Fn-f, included as a positive control, but enhance cartilage matrix damage to a similar extent as Fn-f.
Hyaluronan fragments, as products of cartilage degradation, enhance catabolic processes through enhanced MAP kinase and MMP activity
It is also suggested that another enzyme, aggrecanase-2, or ADAMTS-5 (a disintegrin and MMP domain with thrombospondin motifs), plays a predominant role in the proteolysis of OA cartilage aggrecan.
DMOAD developments: present and future
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