ADAMTSaf5

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ADAMTSaf5

An ADAMTSs family enzyme encoded by ADAMTS5 on chromosome 21q21.3 which, like ADAMTS4, cleaves aggrecan, the major proteoglycan of cartilage. It is highly expressed in placenta and appears to play a role in proteolytic processing during the peri-implantation period. It may be upregulated in arthritic diseases.
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Small Molecules to Inhibit ADAMTS-5 for Osteoarthritis 31
Asahi Kasei Pharma Corp. - Product Pipeline Review -- 2015 Is Released
The primary antibodies included rabbit polyclonal antibodies specific for ADAMTS-1 (1:50; Abcam, Cambridge, United Kingdom), ADAMTS-4 (1:50; AVIVA Systems Biology, San Diego, California), ADAMTS-5 (1:100; Novus, Littleton, Colorado), ADAMTS-14 (1:100, Abcam), and rabbit polyclonal IgG purified from preimmune serum samples (1:50 or 1:100, ab27478; Abcam).
ADAMTS-5 was intermediately expressed in the cytoplasm of the intermediate trophoblasts and weakly expressed in the cytoplasm of cytotrophoblasts and villous stromal cells.
In contrast, ADAMTS-4 and ADAMTS-5 were generally expressed at weaker intensities (Figure 2).
Unlike in the normal placenta, ADAMTS-5 was more strongly expressed in the gestational trophoblastic disease samples: its expression was intermediate in PSTTs and the invasive moles and strong in the choriocarcinomas (Figure 3, C; Figure 4, C; Figure 5, C).
To further investigate the diagnostic usefulness of differential expression patterns of ADAMTS, immunohistochemistry of ADAMTS-1 and ADAMTS-5 was performed on 10 additional cases of early complete moles and normal gestation.
Similarly, murine placenta exhibited limited ADAMTS-5 expression during the early-trimester and periimplantation period (day 7.
19,20) ADAMTS-4 and ADAMTS-5 are known as aggrecanse-1 and aggrecanse-2, respectively, because of the major roles they have during the early stages of cartilage destruction in osteoarthritis and rheumatoid arthritis.
1) ADAMTS-4 and ADAMTS-5 have also been reported to be upregulated in proliferating glioblastoma cells in the brain.
Differential Expression Patterns of a Disintegrin and Metalloproteinase With Thrombospondin Motifs (ADAMTS) -1, -4, -5, and -14 in Human Placenta and Gestational Trophoblastic Diseases
5-kDa HA-fs enhance MMPs, including MMP -3 and 13 but not an ADAMTS-5 in chondrocytes and cartilage explant cultures, to a lesser extent than a Fn-f, included as a positive control, but enhance cartilage matrix damage to a similar extent as Fn-f.
Hyaluronan fragments, as products of cartilage degradation, enhance catabolic processes through enhanced MAP kinase and MMP activity
It is also suggested that another enzyme, aggrecanase-2, or ADAMTS-5 (a disintegrin and MMP domain with thrombospondin motifs), plays a predominant role in the proteolysis of OA cartilage aggrecan.
At this time, MMP-13 and ADAMTS-5 (8,9) are identified as the most attractive targets for the treatment of OA, as recent reports have shown that both these enzymes are the predominant ones involved in the OA process.
DMOAD developments: present and future
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