ADAMTSaf5

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ADAMTSaf5

An ADAMTSs family enzyme encoded by ADAMTS5 on chromosome 21q21.3 which, like ADAMTS4, cleaves aggrecan, the major proteoglycan of cartilage. It is highly expressed in placenta and appears to play a role in proteolytic processing during the peri-implantation period. It may be upregulated in arthritic diseases.
References in periodicals archive ?
5-kDa HA-fs enhance MMPs, including MMP -3 and 13 but not an ADAMTS-5 in chondrocytes and cartilage explant cultures, to a lesser extent than a Fn-f, included as a positive control, but enhance cartilage matrix damage to a similar extent as Fn-f.
It is also suggested that another enzyme, aggrecanase-2, or ADAMTS-5 (a disintegrin and MMP domain with thrombospondin motifs), plays a predominant role in the proteolysis of OA cartilage aggrecan.
At this time, MMP-13 and ADAMTS-5 (8,9) are identified as the most attractive targets for the treatment of OA, as recent reports have shown that both these enzymes are the predominant ones involved in the OA process.