ADAMTSbi18

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ADAMTSbi18

An ADAMTSs family enzyme encoded by ADAMTS18 on chromosome 16q23 which has a sequence similarity to ADAMST16. It is expressed in fetal lung and liver and in adult prostate and brain. It is thought to have tumour suppressor activity.
References in periodicals archive ?
Although most of the ADAMTS subtypes exhibited a similar pattern with decreased expression levels in preeclamptic placentas, the expression level of ADAMTS-18 appeared to be significantly higher in preeclamptic placentas than in controls (Figure 3a, 3c).
Mutations in ADAMTS-18 gene, and methylation of promoter region of ADAMTS-18 gene are highly linked to several tumors, indicating that ADAMTS-18 acts as a tumor suppressor gene (31-33).
Li, "ADAMTS-18: a metalloproteinase with multiple functions," Frontiers in Bioscience, vol.