ADAMTSbe14

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ADAMTSbe14

An ADAMTSs family enzyme encoded by ADAMTS14 on chromosome 10q21.3 which has physiologic aminoprocollagen peptidase activity and is structurally homologous with ADAMTS2 and ADAMTS3. It is said to be upregulated in breast cancer.
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The primary antibodies included rabbit polyclonal antibodies specific for ADAMTS-1 (1:50; Abcam, Cambridge, United Kingdom), ADAMTS-4 (1:50; AVIVA Systems Biology, San Diego, California), ADAMTS-5 (1:100; Novus, Littleton, Colorado), ADAMTS-14 (1:100, Abcam), and rabbit polyclonal IgG purified from preimmune serum samples (1:50 or 1:100, ab27478; Abcam).
ADAMTS-14 was expressed at intermediate levels in the cytoplasm of all 3 types of trophoblasts and was weakly but positively expressed by the villous stromal cells compared with that of a negative control (Figure 1, E and F).
In the second-trimester and third-trimester placentas, the patterns and intensities of ADAMTS-1 and ADAMTS-14 expression in the 5 cell types were similar to those in the first-trimester placenta.
ADAMTS-14 showed consistently intermediate positivity in all cases of gestational trophoblastic diseases (data not shown).
Among them, ADAMTS-1, -4, and -5 showed different expression patterns between normal placental tissue and gestational trophoblastic diseases, while the staining patterns of ADAMTS-14 in placentas obtained from patients diagnosed as having gestational trophoblastic diseases did not differ from the staining patterns observed in normal placenta.
Association of a nsSNP in ADAMTS-14 to some osteoarthritis phenotypes.
E, ADAMTS-14 immunohistochemical staining shows intermediate cytoplasmic positivity in syncytiotrophoblasts, cytotrophoblasts, and intermediate trophoblasts.