ADAMTSab1

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ADAMTSab1

An ADAMTS family protease encoded by ADAMTS1 on chromosome 21q21.2, which is antiangiogenic (ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, thrombospondin-1, or endostatin). ADAMTS1 is associated with acute inflammation and various inflammatory processes and with the development of cancer cachexia. ADAMTS1 expression is induced by IL1 and appears to be necessary for normal growth, fertility (it is up-regulated by progesterone during ovulation, and may play a critical role in follicular rupture), organogenesis and organ function. ADAMTS1 activity is blocked by some metalloprotease inhibitors, including TIMP-2 and TIMP-3. Thrombospondin proteolysis is decreased or absent in ADAMTS1 knock-out mice and associated with delayed wound closure and increased angiogenesis.
References in periodicals archive ?
ADAMTS-1 levels were not significantly lower in PCOS group (p = 0.959).
In the PCOS group, a statistically significant positive correlation was determined only between ADAMTS-1 and versican levels (r = 0.615, p < 0.001).
In addition, a statistically significant positive correlation was determined between serum ADAMTS-1 and versican levels in the PCOS group.
ADAMTS-1 is shown to be secreted mainly by mural granulosa cells, localized to the ECM of expanded COCs and induced markedly by LH in ovulating follicles (18,25).
Consistent with our result, Richards et al (27) demonstrated that versican was the primary substrate in COCs not only for ADAMTS-1 but also for ADAMTS-4 and 5, and they were all expressed in spatiotemporal patterns suggesting evident and probable overlapping functions with each other.
ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary.
Thus, all 3 PSTTs and 3 of 4 choriocarcinomas expressed ADAMTS-1 strongly, whereas the 4 invasive moles exhibited only intermediate positivity (Figure 3, A; Figure 4, A; Figure 5, A).
To further investigate the diagnostic usefulness of differential expression patterns of ADAMTS, immunohistochemistry of ADAMTS-1 and ADAMTS-5 was performed on 10 additional cases of early complete moles and normal gestation.
ADAMTS-1, -4, -5, and -14 were expressed with different staining patterns and intensities depending on the trimester and cell type.
The observations in the present study are consistent with those of a previous study (3) that detected the messenger RNAs of several ADAMTS subtypes, including ADAMTS-1, -4, and -5, in first-trimester human placenta by polymerase chain reaction.
Of the various ADAMTS subtypes, the best characterized seem to be ADAMTS-1, -4, and -5, which have overlapping activities such as proteolytic modification of cell surface proteins and the extracellular matrix.
Among them, ADAMTS-1, -4, and -5 showed different expression patterns between normal placental tissue and gestational trophoblastic diseases, while the staining patterns of ADAMTS-14 in placentas obtained from patients diagnosed as having gestational trophoblastic diseases did not differ from the staining patterns observed in normal placenta.