ADAMTSab1

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ADAMTSab1

An ADAMTS family protease encoded by ADAMTS1 on chromosome 21q21.2, which is antiangiogenic (ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, thrombospondin-1, or endostatin). ADAMTS1 is associated with acute inflammation and various inflammatory processes and with the development of cancer cachexia. ADAMTS1 expression is induced by IL1 and appears to be necessary for normal growth, fertility (it is up-regulated by progesterone during ovulation, and may play a critical role in follicular rupture), organogenesis and organ function. ADAMTS1 activity is blocked by some metalloprotease inhibitors, including TIMP-2 and TIMP-3. Thrombospondin proteolysis is decreased or absent in ADAMTS1 knock-out mice and associated with delayed wound closure and increased angiogenesis.
References in periodicals archive ?
In summary, ADAMTS-1, -4, -5, and -14 are differentially expressed in the human placenta throughout gestation in a time-specific and cell-specific manner.
Differential effects of interleukin-1[beta] and transforming growth factor-[beta]1 on the expression of the inflammation-associated protein, ADAMTS-1, in human decidual stromal cells in vitro.
METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angioinhibitory activity.
ADAMTS-1 is essential for the development and function of the urogenital system.
Comparison of ADAMTS-1, -4, and -5 expression in culprit plaques between acute myocardial infarction and stable angina.
ADAMTS-1 mediates the release of antiangiogenic polypeptides from TSP1 and 2.
A, ADAMTS-1 immunohistochemical staining shows strong cytoplasmic and nuclear positivity (inset) in trophoblasts and endothelial cells.
A, ADAMTS-1 immunohistochemical staining maintains strong positivity in trophoblasts and endothelial cells and shows decreased expression in multinucleated invasive trophoblasts (inset).
A and B, ADAMTS-1 and ADAMTS-4 immunohistochemical staining, respectively, shows strong positivity in PSTTs.