ADAM33

ADAM33

An enzyme of the metalloprotease-disintegrin family found mainly on the surface membranes of airway smooth muscle cells. There has been speculation that this enzyme may be involved in the remodelling of airway muscle layers that occurs in severe chronic ASTHMA.
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(8) More than 100 genomic loci have been reported to be linked with asthma disease susceptibility; (2) among them ADAM33 is a major asthma susceptible candidate gene.
To date, several studies have identified many genes associated with asthma development, but localization of the IgE receptor (Fc[epsilon]RI) gene on chromosome 11q, cytokine gene on chromosome 5q and ADAM33 gene on chromosome 20p13 drew biggest attention (16-18).
These include genes such as ADAM33 (a disintegrin and metalloprotease33) [49], TLR2 and TLR4 (toll-like receptor 2 and 4) [50], MCP-1 (monocyte chemoattractant protein-1) and RANTES (regulated upon activation normal T cell expressed and secreted) [51], TNFa (tumor necrosis factor alpha) [52], PON1 (paraoxonase) [53], IL-4 and IL-10 (interleukins) [54], HLA [55], VEGF (vascular endothelial growth factor) [56], and ERAP (endoplazmic reticulum aminopeptidase) [57].
ADAM33 (ADAM Metallopeptidase Domain 33) is an asthma susceptible gene, and is associated with asthma and bronchial hyper-responsiveness (10).
Rose-Zerilli et al., "ADAM33 expression in atherosclerotic lesions and relationship of ADAM33 gene variation with atherosclerosis," Atherosclerosis, vol.
ADAM33 is a member of ADAM family that is associated with keloid scars in the northeastern Chinese population (36).
The gene ADAM33 had been linked to the development of the condition.
Single nucleotide polymorphisms V4 and T1 of the ADAM33 gene in Venezuelan patients with asthma or chronic obstructive pulmonary disease.
Furthermore, our recent data show that an injection of 300 mg of hydrocortisone (=60 mg prednisone) suppresses the expression of IL-4, LTBR, ADAM33, and MMP-9 and the plasma concentration of MCP-1.
Asthma is believed to have a strong genetic background, and hundreds of genes have been identified to be related with asthma, including GSTM1, IL10, CTLA-4, SPINK5, LTC4S, IL4R, and ADAM33 [9].
Previous research has shown the role of gene (http://www.medicalnewstoday.com/articles/261029.php) ORMDL3 , (http://acc6.its.brooklyn.cuny.edu/~scintech/asthma/Genetics2.htm) ADAM33, (http://www.who.int/genomics/about/Asthma.pdf) PHF11, DPP10, GRPA and SPINK5 in asthma.