ADAM1cia28

(redirected from ADAM23)

ADAM1cia28

An ADAMs family protein encoded by ADAM28 on chromosome 8p21.2, which is expressed on lymphocytes in two transcript variants based on alternative splicing—a shorter secreted isoform, and a longer transmembrane isoform. ADAM28 is thought to play a role in adhesive and proteolytic events that occur during lymphocyte emigration and may be involved in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. Cleavage is inhibited by TIMP-3 and TIMP-4.
References in periodicals archive ?
ADAM2, ADAM7, ADAM11, ADAM18, ADAM22, ADAM23, ADAM29, and ADAM32 lack the consensus sequence HExGHxxGxxHD for metalloproteinase activity.
Similar to ADAM15, the proteolytically inactive ADAM23 can function as adhesion molecule by binding to the [[alpha].sub.v][[beta].sub.3] integrin and promoting cell-cell interactions and concomitantly modulating metastasis by reducing migration and adhesion to vitronectin [220].
Costa et al., "ADAM23 negatively modulates alpha(v)beta(3) integrin activation during metastasis," Cancer Research, vol.
Some examples are Tp53 [39], PTEN [40], VEGF [41], and ADAM23 [42].
Shinjo et al., "ADAM23 methylation and expression analysis in brain tumors," Neuroscience Letters, vol.