PSEN2

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PSEN2

A gene on chromosome 1q31-q42 that encodes a probable catalytic subunit of the gamma-secretase complex, which catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. It may play a role in intracellular signalling and gene expression, or in linking chromatin to the nuclear membrane; it may also play a role in sorting proteins in the cytoplasm.

Molecular pathology
Defects in PSEN2 are a cause of Alzheimer disease type 4 and cardiomyopathy dilated type 1V.
References in periodicals archive ?
In addition, a combination of doxorubicin with a-fetoprotein- (AFP-) E1A-IRESE1B bicistronic cassette derived from Ad5, CV890 showed a synergic antitumor effect in vitro as well as in vivo [74].
The situation changes at the beginning of the seventeenth century, with the number of the -aunce tokens suddenly dropping in Ad2, and continuing to decrease in Ad3 and Ad4 until they disappear completely in Ad5.
(7) Similarly it was argued that, while being an uncircumcised vaccinee was a risk factor on its own, Ad5 seropositivity is only a risk factor in conjunction with being uncircumcised and that 'pre-existing immunity to Ad5, in and of itself ...
The Ad serotype 5 (Ad5) vector used in this study was a replication defective vector encoding bacterial [beta]-galactosidase (lacZ) gene as a marker.
Baseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of aadenovirus-specific CD4+ T cells.
But David Weiner counters that "the same question could be raised for antibody approaches following the VaxGen studies (26,27) where antibodies had no impact." The University of Pennsylvania vaccine expert explains that the Merck vaccine "induced a low level of interferon-gamma ELISPOT response against perhaps only three [viral] epitopes at a very low magnitude, well below those levels in infected persons that control infection." On top of that, the vaccine stirred such responses in only 60% to 70% of vaccinated people, and higher HIV incidence in people with high Ad5 levels confused interpretation of results.
"Uncircumcised males [with high Ad5 immunity] who received the vaccine were approximately four times more likely than those who received placebo to become infected with HIV," Dr.
actually increased the risk of HIV infection in some study participants (those with high levels of antibodies to the virus which causes the common cold, adenovirus 5 (Ad5) and a component of the vaccine) and was ineffective in the rest of study participants.
Importantly, the effect of pre-existing Ad5 immunity on immunogenicity of the vaccine appeared to be small.
Los tipos mas frecuentemente asociados a estos cuadros son Ad3, Ad4, Ad7, Ad21, asi como Ad2 y Ad5. Se han descrito las secuelas de dano pulmonar residual importante como bronquiectasias y bronquiolitis (1,4-6).
The AdVac technology is specifically designed to manage the problem of pre-existing immunity in humans against the most commonly used recombinant vaccine vector, adenovirus serotype 5 (Ad5), without compromising large-scale production capabilities or the immunogenic properties of Ad5.