PSEN2

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PSEN2

A gene on chromosome 1q31-q42 that encodes a probable catalytic subunit of the gamma-secretase complex, which catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. It may play a role in intracellular signalling and gene expression, or in linking chromatin to the nuclear membrane; it may also play a role in sorting proteins in the cytoplasm.

Molecular pathology
Defects in PSEN2 are a cause of Alzheimer disease type 4 and cardiomyopathy dilated type 1V.
References in periodicals archive ?
Thanks to the changes in selection methods and in particular the use of computer tests, put in place globally for the first time, 37,000 applicants for the AD5 concours (administrators) were able to register, reserve a place and sit their tests in less than two months from the date that the concours was published.
The recruitment of translators will be at graduate entry grade (AD5), while for interpreters, recruitment will be at both AD5 and AD7, the latter of which requires more professional experience.
The Bureau seeks an additional 70 staff members for committee secretariats (50 AD5 administrators and 20 AST1 assistants).