ACVR2B


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ACVR2B

A gene on chromosome 3p22 that encodes activin receptor type IIB, a receptor that forms a complex with other type-I and two type-II  transmembrane serine/threonine kinase receptors for activin, a dimeric growth and differentiating factor belonging to the TGF-beta superfamily of structurally related signalling proteins. Type-I receptors are essential for signalling; type-II receptors are required for binding ligands and expression of type-I receptors. After activin binding, type-I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors, playing roles in cell differentiation, growth arrest and apoptosis.
References in periodicals archive ?
Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB.
ActA binds to type II receptor, ACVR2A or ACVR2B, leading to oligomerization, which recruits and phosphorylates the activin type I receptor-like kinase 4 (ALK4, or also known as ACVR1B) (reviewed in [26]).
To understand the influence of an ActA addition on the expression of members of the TGF-[beta] signaling pathway during our ESC EB-based cardiac differentiation in a human setting, gene expression analyses were performed for NODAL, CRIPTO-1, and the transmembrane types I (ALK4 or ACVR1B) and II (ACVR2A and ACVR2B) activin receptors.