ACVR1B


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ACVR1B

A gene on chromosome 12q13 that encodes activin receptor type IB, a receptor that forms a complex with other type-I and two type-II  transmembrane serine/threonine kinase receptors for activin, a dimeric growth and differentiating factor belonging to the TGF-beta superfamily of structurally related signalling proteins. Type-II receptors phosphorylate and activate type-I receptors, which autophosphorylate, then bind and activate SMAD transcriptional regulators, playing roles in cell differentiation, growth arrest and apoptosis. 

Molecular pathology
ACVR1B mutations are associated with pituitary tumours.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Ninomiya et al., "miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b," FEBS Letters, vol.
ActA binds to type II receptor, ACVR2A or ACVR2B, leading to oligomerization, which recruits and phosphorylates the activin type I receptor-like kinase 4 (ALK4, or also known as ACVR1B) (reviewed in [26]).
Griffin et al., "Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%," Cancer Research, vol.
They discovered that four genes (named TENC1, ERBB3, ACVR1B, and DGKA) influence LDL levels.
From Table 3, in addition to TGF-131, the genes belong to TGF beta receptors, ACVR1B and TGFBR2, and co-activators, CREBBP, were up-regulated in NF3 treated fibroblast Hs27 cells.
ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma.