ACTN1


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ACTN1

A gene on chromosome 14q24.1 that encodes an actin-binding bundling protein expressed in various cells, playing different roles in each. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane; skeletal, cardiac and smooth muscle isoforms are localised to the Z-disc and analogous dense bodies, where they help anchor myofibrillar actin filaments.
References in periodicals archive ?
Interestingly, only actin-like proteins were pulled down, such as ACTN1, ACTN4, and actin cytoplasmic 2 (ACTG1).
As shown in Figure 4(a), RT-PCR analysis revealed the appropriate expression of various cardiac marker genes, including a myosin heavy chain (Myh6), [beta] myosin heavy chain (Myh7), myosin light chain-2a (Myl7), Myl2, [alpha]-sarcomeric actinin (Actn1), and natriuretic peptide type B (Nppb).