In 1994, Greenman and Melmed analyzed SSTR 3, SSTR4, and SSTR5 in 33 pituitary adenomas and SSTR1 and SSTR2 in 27 pituitary adenomas using RT-PCR, including 2 and 3 ACTH-producing adenomas
A bivariate plot based on principal components with an ellipse drawn around each K-means cluster is illustrated in Figure 1 for the validation set, which shows clustering of biologically relevant groups including gonadotroph adenomas adjacent to an IHC null cell group, Pit-1 family tumors, and ACTH-producing adenomas
. Sensitivity analysis (not shown) showed only modest differences of within-cluster sum of squares above K = 6, so 6 clusters are illustrated.
The concurrent use of TMZ and radiotherapy appears to be a helpful alternative for the treatment of rapidly growing, aggressive pituitary ACTH-producing adenomas
resistant to conventional treatment.
Piscopello et al., "Rare case of Cushing's disease due to double ACTH-producing adenomas
, one located in the pituitary gland and one into the stalk," Hormones, vol.
Interestingly, in their database, ACTH-producing adenomas
were the most prevalent in the group of pituitary-secreting adenomas with GHD.
Furthermore, lower VEGF found in ACTH-producing adenomas
may be consistent with the finding that VEGF production can be suppressed by glucocorticoids which are potent inhibitors of VEGF production in vitro .