ACTH stimulation test


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ACTH stim·u·la·tion test

a test for adrenal cortical function; ACTH administered by bolus, continuous intravenous infusion, or intramuscularly, evokes an increase in plasma cortisol in normal persons; in adrenal cortical insufficiency, the expected increase in plasma cortisol is limited or nonexistent.

ACTH stimulation test

A test to determine the presence of adrenal insufficiency.

Patient care

Synthetic adrenocorticotropic hormone (ACTH) is injected intravenously, and the serum cortisol level is measured at timed intervals (30 or 60 min after the injection). A patient with normal adrenal function will respond to the test with increased serum cortisol levels above 18 µg/dl. Serum cortisol levels < 15 µg/dl are diagnostic of adrenal insufficiency. The test has been traditionally performed with an injection of 250 µg of ACTH, but studies have shown that 1 µg is an equally effective test dose.

Synonym: Cortrosyn stimulation test; cosyntropin stimulation test

ACTH stim·u·la·tion test

(stimyū-lāshŭn test)
Measurement of adrenal cortical function.
References in periodicals archive ?
The ACTH stimulation test is more reliable than an unstimulated test for assessing the capacity of the adrenal glands to respond to a stressor.
6) found that cortisol values in the 60th minute in a 1 mcg low-dose ACTH stimulation test (LDT) were significantly lower in the BD group than in the control group.
During the short postoperative ACTH stimulation test, cortisol values at 0, 30, 60, 90 and 120 minutes were 8.
We have not performed the high-dose ACTH stimulation test (250 [micro]g of synthetic ACTH 1-24 per 1.
Individuals were screened for diabetes and adrenal insufficiency, with basal cortisol levels and an ACTH stimulation test at the time of study entry and were excluded if either was identified.
If the clinical suspicion is high but cortisol levels are normal, an ACTH stimulation test provides the best assessment of adrenal function.
Although the ACTH stimulation test is best for confirming a diagnosis, as a screen it produced two false-positive results.
When the response to the short ACTH test is abnormal, a "long" ACTH stimulation test is required to determine the cause of adrenal insufficiency.
Cortisol, DHEAS and 17OHP showed no response to ACTH stimulation test.
The low-dose short ACTH stimulation test (LDST) has been shown to correlate well with IIH in such cases (4-7).
We used zero and 30 minutes values of serum cortisol in ACTH stimulation test, to assess the pituitary ACTH reserve.