ACTH stimulation test


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ACTH stim·u·la·tion test

a test for adrenal cortical function; ACTH administered by bolus, continuous intravenous infusion, or intramuscularly, evokes an increase in plasma cortisol in normal persons; in adrenal cortical insufficiency, the expected increase in plasma cortisol is limited or nonexistent.
Farlex Partner Medical Dictionary © Farlex 2012

ACTH stimulation test

A test to determine the presence of adrenal insufficiency.

Patient care

Synthetic adrenocorticotropic hormone (ACTH) is injected intravenously, and the serum cortisol level is measured at timed intervals (30 or 60 min after the injection). A patient with normal adrenal function will respond to the test with increased serum cortisol levels above 18 µg/dl. Serum cortisol levels < 15 µg/dl are diagnostic of adrenal insufficiency. The test has been traditionally performed with an injection of 250 µg of ACTH, but studies have shown that 1 µg is an equally effective test dose.

Synonym: Cortrosyn stimulation test; cosyntropin stimulation test
Medical Dictionary, © 2009 Farlex and Partners

ACTH stim·u·la·tion test

(stimyū-lāshŭn test)
Measurement of adrenal cortical function.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
The two main tests are the low-dose dexamethasone suppression test (LDDST) and the ACTH stimulation test, but there are several other companion tests that may be recommended including the urine cortisohcreatinine ratio and advanced imaging such as abdominal ultrasound.
However, they will take blood samples from any dog with a documented diagnosis with an ACTH stimulation test and an abnormal serum sodiunm:potassium ratio.
[15] Clinicians utilising the ACTH stimulation test need to be aware of several pitfalls.
Urgent ACTH stimulation test was carried out with 0.25 mg synthectin.
The ACTH stimulation test involves injection of artificial ACTH to see if your cat's body responds with an excess of Cortisol production.
Therefore, it has several limitations, especially regarding the number of subjects studied and also use of single method, the ACTH stimulation test, as a screening tool.
ACTH Stimulation Test. Administration of cosyntropin (1-24 ACTH; Cortrosyn) to directly stimulate adrenal cortisol release is the most commonly used diagnostic test to evaluate adrenal function.
Use of the ACTH stimulation test has been reported in kidney transplant patients, but this test requires multiple blood draws and synthetic ACTH is expensive [21].
Therefore, we reviewed the results of the ACTH stimulation test performed over a 10-year period to evaluate adrenal function in 69 CF patients and compared the clinical characteristics of CF patients with AI to those of adrenal-sufficient (AS) patients.
On follow-up, low dose (1 [micro]g) ACTH stimulation test was performed, and adrenal deficiency was confirmed (peak cortisol: 12.1 [micro]g/dl).
[5] Our study aims to diagnose adrenal insufficiency in critically ill patients on the basis of ACTH stimulation test.
ACTH stimulation test was performed on 104 females (52 carriers and 52 noncarriers).