It has been suggested that the ACTH receptor
gene could provide the link to explain the association of the three main features of this syndrome, since there is evidence that ACTH has some neuropathic effects.21,22
Mutations in MC2R (encoding the ACTH receptor
protein, MC2R) and MRAP (encoding MC2R accessory protein) are well described causes of inherited disorders of ACTH binding and signaling, namely FGD type 1 (FGD1) and type 2 (FGD2).
Research article: "Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor
in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary." J.
ACTHR is ACTH receptor
. Western blot analysis showed that there was a detectable signal of ACTHR in the pituitary gland and adrenal cortex.
In this regard in regenerating adrenals we have followed the pattern of expression of Mc2r gene (ACTH receptor
In another approach to block adrenocorticotropic hormone (ACTH) and pituitary adenylate cyclase-activating protein (PACAP) receptors, we quantified protein levels of GH in the rat GH3 pituitary tumor cell line (ATCC) after treatment with 5 or 10 [micro]L ACTH receptor antibody (Santa Cruz Biotechnology, Santa Cruz, CA) at a concentration of 0.2 mg/m.L, 15 min before treatment with 1 ppm ATR.
To minimize the effect of ACTH on GH, we saturated rat GH3 pituitary cells with incremental amounts of ACTH receptor antibody before applying ATR.
NAC Induces Adrenal Hypertrophy and Upregulation of ACTH Receptor
and StAR in the Adrenal Cortex of Wistar Rats.
Defects in the ACTH receptor
(MC2R) and accessory proteins can result in adrenal glands unresponsive to ACTH, leading to reduced synthesis of steroid hormones required for downstream developmental events (1).
The previous fellow, Robert Lefkowitz, who is a big professor at Duke now, a terrific guy, had worked on this way of measuring ACTH receptors
. It was very early in the receptor game, and Jesse was very excited about this.
Hypersecretion of adrenal without ACTH receptors
was suspected in the tumor adrenal cells.