MC2R

(redirected from ACTH receptor)
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MC2R

A gene on chromosome 18p11.2 that encodes ACTH receptor, the activity of which is mediated by G protein-activated adenylate cyclase.

Molecular pathology
Genetic variations in MC2R cause glucocorticoid deficiency type 1.
References in periodicals archive ?
Drugs profile discussed in this report include ALD-1613, AT-814, ATR-101, DG-3173, ISIS-GCCRRx, ketoconazole, LCI-699, mifepristone, MPP-482, pasireotide LAR, Peptides to Antagonize ACTH Receptor for Cushing's Syndrome, Small Molecule to Antagonize Melanocortin Receptor 2 for Cushing's Disease, Small Molecule to Inhibit CYP11B1 for Cushing's Disease and Subclinical Hypercortisolism, Small Molecules to Antagonize Steroidogenic Factor-1 for Endometriosis, Cancer and Cushing's Disease, Small Molecules to Inhibit Cortisol for Metabolic Disorders, Small Molecules to Modulate Cryptochrome for Metabolic and CNS Disorders.
In another approach to block adrenocorticotropic hormone (ACTH) and pituitary adenylate cyclase-activating protein (PACAP) receptors, we quantified protein levels of GH in the rat GH3 pituitary tumor cell line (ATCC) after treatment with 5 or 10 [micro]L ACTH receptor antibody (Santa Cruz Biotechnology, Santa Cruz, CA) at a concentration of 0.
The previous fellow, Robert Lefkowitz, who is a big professor at Duke now, a terrific guy, had worked on this way of measuring ACTH receptors.