ACTH


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ACTH

 

ACTH

Abbreviation for adrenocorticotropic hormone (also called corticotropin).
Synonym(s): corticotropin (3)

ACTH

(ā′sē′tē′āch′)
n.
A hormone produced by the anterior lobe of the pituitary gland that stimulates the secretion of cortisol and other hormones by the adrenal cortex. Also called adrenocorticotropin, corticotropin.

ACTH

A 39-amino acid hormone produced by the anterior pituitary gland, which regulates adrenocortical activity, stimulating release of cortisol, mineralocorticoids, and adrenal androgens; pituitary ACTH is regulated by corticotropin-releasing hormone (CRH).
Daily pattern ACTH levels vary over the space of a 24-hour day, peaking at 6–8 am and evening 6–11 pm; ACTH suppression or stimulation testing may be required to confirm the diagnosis of changes in adrenal function.
ACTH increased in Addison’s disease, congenital adrenal hyperplasia, Cushing disease, pituitary-dependent Cushing syndrome, ectopic ACTH-producing tumours, Nelson syndrome.
ACTH decreased in Secondary adrenocortical insufficiency, adrenal carcinoma, adenoma. 
Ref range < 120 pg/mL

ACTH

Adrenocorticotrophic hormone Endocrinology A 39-amino acid hormone produced by the anterior pituitary gland, which regulates adrenocortical activity, stimulating release of cortisol, mineralocorticoids, and adrenal androgens; pituitary ACTH is in turn regulated by corticotropin-releasing hormone–CRH; ACTH is ↑ in pituitary-dependent Cushing syndrome Daily pattern ACTH levels vary over the space of a 24 hr day, peaking at 6–8 am and 6–11 pm; ACTH suppression or stimulation testing may be necessary to confirm the diagnosis of changes in adrenal function; ACTH is ↑ in Addison's disease, congenital adrenal hyperplasia, Cushing's disease, ectopic ACTH-producing tumors, Nelson syndrome; ACTH is ↓ in 2º adrenocortical insufficiency, adrenal carcinoma, adenoma. See Cushing syndrome.

ACTH

Abbreviation for adrenocorticotropic hormone.

ACTH

Adrenocorticotropic HORMONE. This hormone is produced by the pituitary gland, on instructions from the hypothalamus (the part of the brain immediately above the gland) when a stressful situation arises. ACTH is carried by the blood to the adrenal glands and prompts them to secrete the hormone cortisol into the bloodstream. ACTH is sometimes used as medication.

ACTH

see ADRENOCORTICOTROPIC HORMONE.

ACTH

Adrenocorticotropic hormone, a hormone normally produced by the pituitary gland, sometimes taken as a treatment for arthritis and other disorders.
Mentioned in: Anaphylaxis

ACTH

Abbreviation for adrenocorticotropic hormone.
References in periodicals archive ?
Inferior petrosal sinus sampling is an invasive test in which the venous channels draining pituitary gland are sampled for ACTH levels.
The benefit to the ACTH stimulation test is the short duration (two hours between first blood draw, injection, and second sample), and it is less affected by non-adrenal gland illness.
Indicator Results Normal reference Capillary blood gas PH: 6.9 (7.35-7.45) Serum Na (sodium) 128 mmol/L (135-148) Serum K (potassium) 6.2 mmol/L (3.5-5.0) Serum Cl (chlorine) 90.6 mmol/L (98-108) Serum osmolality 274.1 mmol/L (280-298) Glucose 59 mg/dL (70-110) Calcium 10.3 mg/dL (8.6-10.8) Urea 88 mg/dL (10-50) Creatinine 0.9 mg/dL (0.5-1.3) Aldosterone 5.8 ng/dL (5.0-132) Plasma renin 233 pg/mL (6.0-80.0) ACTH stimulation test ACTH 42.8 pg/mL (5-60) Serum cortisol 9.0 [micro]g/dL at 0 min (2.3-12.3) 52.4 [micro]g/dL at 60 min 17-OH progesterone Not increased ACTH--adrenocorticotropic hormone Table 2--Laboratory findings for twin A at 7 months of age.
Current suggestion of >10 ng/mL 17-OH-P is usually regarded as a sensitive level for capturing a larger group, but its specificity may be lower compared to the cut-off values such as 14 or even 15 ng/mL concentration of 17-OH-P after ACTH stimulation, which reaches almost 100% specificity (7,8,15,22,23).
By use of the 10-steroid combination, all patients with ectopic ACTH secretion were correctly classified, only 1 patient with adrenal CS was incorrectly classified, and most of the patients with pituitary CS were correctly classified (Fig.
A diagnosis of primary AI is confirmed if the serum cortisol level is < 18 mcg/dL, in the presence of markedly elevated ACTH and plasma renin activity.
Measurement of plasma ACTH differentiated ACTH-dependent CS (ACTH [greater than or equal to] 10 pg/mL) from ACTH-independent CS (< 10 pg/mL).
This case report describes a patient presenting with nausea and vomiting in the setting of recently taking posaconazole who was found to have failed a cosyntropin test with simultaneous elevated ACTH suggesting posaconazole-induced primary adrenal insufficiency that resolved after discontinuation of the medication.
A high-dose dexamethasone suppression test revealed elevations of ACTH (319pg/ml) and cortisol (131.5 [micro]g/dl), consistent with ACTH-dependent hypercortisolism and SAME (Table 1) from an ectopic nonsuppressible source of ACTH.
Treatment with single-agent abiraterone results in deficient glucocorticoid synthesis and consequently leads to a compensatory upregulation of hypothalamic-pituitary-adrenal (HPA) with raised levels of adrenocorticotrophic hormone (ACTH) [5].