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carbon tetrachloride (CCl4)

Etymology: L, carbo + Gk, tetra, four, chloros, greenish
a colorless, volatile toxic liquid used as a solvent. CCl4 is particularly toxic to the kidneys and liver; permanent damage to these organs may result from exposure.


A chemokine encoded by CCL4 (formerly LAG1, SCYA4), located on chromosome 17q21-q23, which precipitates local inflammatory response characterised by infiltration of neutrophils. It is expressed after cell activation by mitogens (phytohemagglutinin, bacterial endotoxins or Staphylococcus aureus) and IL2, and inhibited by glucocorticoids, TGF-beta and cyclosporin A.

Normal expression
T-cells, B-cells, monocytes.

Abnormal expression
Various tumour cell lines.