ACSS2 | definition of ACSS2 by Medical dictionary
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ACSS2 A gene on chromosome 20q11.22, which encodes a cytosolic enzyme that produces acetyl-CoA from acetate, for use in lipid synthesis and energy generation. ACSS2 expression is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids.
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References in periodicals archive
Caption: Figure 6: Western blotting and mRNA analysis of myocardium: AceCS1, Glut4, PARP, and LC3B protein expression and Slc2a4 and Acss2
gene expression in the perfusion hearts in HFD and control rats in 18 weeks and 36 weeks after high-fat diet feeding.
ACSS1 showed a >3-fold increase, and ACSS2 showed more than 7-fold increase in transcript abundance.
Network analysis shows that FASN, SREBF1, SREBF2, PPARG, and ACSS2 are the major components of the milk fat synthesis pathway.
ACSS1 and ACSS2
only are activated for acetate and acetyl-CoA formation during ethanol metabolism but not during normal sugar metabolism that also results in acetyl-CoA generation.