NF2

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NF2

NF2

A gene on chromosome 22q12.2 that encodes a putative regulator of the Hippo/SWH (Sav/Wts/Hpo) signalling pathway, which plays a key role in tumour suppression by restricting proliferation and promoting apoptosis. NF2 may act as a membrane-stabilising protein, and it may inhibit PI3 kinase by binding to AGAP2 and downregulating its stimulating activity. NF2 suppresses cell proliferation and tumourigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Molecular pathology
NF2 defects cause:
• Neurofibromatosis 2;
• Schwannomatosis; and
• Mesothelioma (some cases).

Neurofibromatosis type 2 (NF2)

A hereditary condition associated with an increased risk of bilateral acoustic neuromas, other nerve cell tumors and cataracts.
Mentioned in: Acoustic Neuroma
References in periodicals archive ?
ACN is a pontifical foundation established to assist the needs of the Church wherever it is oppressed, persecuted or suffering material need.
The fluid resistance is optimized by ensuring the selected termonomer has sufficient polarity based on its solubility parameter, even with lower ACN (acrylonitrile) content in the terpolymer.
Event organiser Lorraine McMahon said: "This year's ACN rally in Scotland was all we have ever wanted it to be.
Separation of ranitidine hydrochloride RANH was chosen as test pharmaceutical for a study on their retention mechanism in HILIC mode by applying a NaOAc/HAc buffer mobile phase with varying ACN content on the two of ZIC-HILIC columns.
Non-FAM-labeled oligonucleotides were prepared with 140 mM KCl, 10 mM Tris-HCl (pH 5.4, 6, or 7.4) and 30-40% (v/v) ACN. The solutions were denatured by heating to 95[degrees]C for 5 minutes and then rapidly cooled for 5 minutes and repeated for five cycles to induce G4/iM formation.
This year's ACN IT Salary Survey will close on 5th September, 2017.
Carole Goldsmith, the BHA's director of people and development, said: "Racing has a plethora of top-class facilities and career opportunities that, through this relationship with ACN, we will be able to share with at-risk young people.
The meeting was organized in the framework of the Anti-Corruption Network (ACN) for Eastern Europe and Central Asia established under the Organization for Economic Cooperation and Development (OECD) Working Group on Bribery.
Several accolades have also been received through the Arabian Computer News ("ACN") Arab Technology Awards over the years, including ACN Arab Technology Best Manufacturing Sector Implementation (2007); ACN Arab Technology Best Manufacturing and Construction Sector Implementation (2008); ACN I.T.
This week's episode began with Wil McAvoy (Jeff Daniels) giving a monologue on Atlantic Cable News (ACN) News Night, reprimanding GOP candidates who kept a blind eye on a debate audience who booed a gay soldier, Stephen Hill when the latter asked a question.
DUBAI Aluminium (Dubal) walked away with two prizes at the annual Arabian Computer News (ACN) Arab Technology Awards, one for the best energy and industry implementation and the other for the chief information officer of the year, granted to Ahmad M Almulla, its vice president for IT.
Summary: The Higher Colleges of Technology (HCT) has taken home the ACN Arab Technology Award for the best Public Sector Implementation in 2012 for its deployment of a cloud-based classroom solution, otherwise known as a Virtual Desktop Infrastructure (VDI), on its Abu Dhabi Men's College campus.