ACER3

ACER3

A gene on chromosome 11q13.5 that encodes a ubiquitously expressed multipass membrane-bound enzyme of the alkaline ceramidase family, which hydrolyses phytoceramide into phytosphingosine and free fatty acid; it is activated by Ca2+, inhibited by Zn2+ and highly expressed in placenta.
References in periodicals archive ?
Five human ceramidase genes have been identified, including ASAH1, ASAH2, ACER1, ACER2, and ACER3, and their protein products are classified as the acid (ASAH1), neutral (ASAH2), and alkaline ceramidase (ACER1-3) subtypes according to their pH optimum for their catalytic activity [9].
demonstrated that loss of acid ceramidase 3 (Acer3), leading to an elevation in C18:1-Cer in blood mononuclear cells (BMCs), aggravates DSS-induced colitis, which is related to the hyperactivation of the innate immune system [126].