ACEI


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ACEI

Abbreviation for angiotensin-converting enzyme inhibitors.

ACE inhibitor

Angiotensin-converting enzyme inhibitor. Any of a family of drugs used to manage hypertension and reduce congestive heart failure (CHF)-related mortality and morbidity.

Examples
Bepridil, captopril, enalapril, lisionopril, losartan, quinapril, ramipril.

ACE inhibitor Effects in Heart Disease
Cardioprotective effects
• Restores balance between myocardial O2 supply and demand;
• Reduces left ventricular preload and afterload;
• Reduces left ventricular mass;
• Reduces sympathetic stimulation.
Vasculoprotective effects
• Antiproliferative and antimigratory effects on smooth muscle and inflammatory cells;
• Antiplatelet effects;
• Improved arterial compliance and tone;
• Improved and/or restored endothelial function;
• Antihypertensive;
• Possible antiatherosclerotic effect. 

Pros
ACEIs are cardioprotective and vasculoprotective; cardioprotective effects include improved haemodynamics and electric stability, reduce sympathetic nervous system (SNS) activity and reduce left ventricular mass; vasculoprotective benefits include improved endothelial function, vascular compliance and tone, and direct antiproliferative and antiplatelet effects. ACEIs also stimulate prostaglandin (PG) synthesis, reduce the size of MIs, and reduce reperfusion injury and complex ventricular arrhythmias.

ACEIs are the treatment of choice in CHF with systolic dysfunction; they are vasodilators which decrease preload and afterload. ACEI-induced reduction in angiotensin II inhibits the release of aldosterone, which in turn reduces sodium and water retention which, by extension, reduce preload; ACEIs improve haemodynamics of CHF by reducing right atrial pressure, pulmonary capillary wedge pressure, arterial BP, as well as pulmonary and systemic vascular resistance; ACEIs increase cardiac and stroke indices by the left ventricle and reduce the right ventricular end-diastolic volumes, thereby increasing cardiac output, while simultaneously reducing cardiac load and myocardial O2 consumption.
 
Adverse effects
• Idiopathic—e.g., rashes, dysgeusia, BMsuppression.
• Class-specific—e.g., hypotension, renal impairment, hyperkaleamia, cough, angioneurotic oedema (the latter 2 of which are mediated by small vasoactive substances—e.g., bradykinin, substance P, and PG-related factors).
References in periodicals archive ?
ACEI is a frequently used medication for hypertension, chronic heart failure, ischemic heart disease, diabetic nephropathy, and progressive renal failure.
AE usually manifests soon after initiating ACEI therapy, but can also manifest only after years of therapy (4).
Much of her work with ACEI has been on an international initiative to improve the quality of inclusive early child care and education.
I look forward to discussing all ACEI events and intiatives with you at our annual conference in Phoenix.
Previous to joining ACEI, Mindi served as the Development Associate for Global Action for Children (GAC) in Washington, D.
Texas A&M University Corpus Christi, Islander ACEI Student President: Jade Munoz Faculty Advisers: Jana Sanders and Norma Zunker
We want to do everything we can to help you promote ACEI membership to your colleagues, fellow teachers, students, and others concerned about the health, welfare, and education of children.
After a 100% success rate with the graduation of Class I candidates, ACEI is preparing for Class II of Leadership ACEI by opening up nominations for mentors and fellows.
Since joining the association in 2004, Jessica has held several ACEI positions, on the state and national levels.
She became active with ACEI in Indiana and gradually expanded her service to include representing ACEI on the national and international levels.
She respects the heritage and history of ACEI, and, at the same, she is aware of the challenges that ACEI faces in the future.
On October 2nd, 2009, ACEI Executive Board members Christine Chen, Vidya Thirumurthy, and Karen Foster accompanied ACEI's Executive Director, Diane Whitehead, on a visit to Capitol Hill in Washington, D.