ACE2

ACE2

(1) Angiotensin-Converting Enzyme 2. An angiotensin-converting enzyme (ACE-like exopeptidase of the dipeptidyl carboxydipeptidase family) which is expressed predominantly in vascular endothelial cells of the heart, kidney and testes.
Physiology ACE2 appears to be a critical regulator of heart function and may counteract ACE activity.
(2) A gene on Xp22 which encodes a variant of angiotensin converting enzyme of the dipeptidyl carboxydipeptidase family, which is expressed on the vascular endothelial cells of the heart, kidneys and testes.

ACE2

Angiotensin-converting enzyme 2 Therapeutics An ACE-like enzyme expressed in vascular endothelial cells of the heart and kidney Physiology ACE2 appears to be a critical regulator of heart function and may counteract ACE activity. See ACE.
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: The market will include a firm order and two slices conditional - Slice farm (Tf): Display with cap ECA1 and ACE2 : - Conditional phase 1 (Tc1) Screen Em2.
Several components of the renin-angiotensin system, including angiotensin (ANG), angiotensin I converting enzyme (ACE), ACE2, and angiotensin II receptor type 1 and type 2 (AGTR1 and AGTR2), are shown in the subnetwork (Figure 3(d)).
White AT cells, particularly white AT adipocytes, are capable of expressing all the RAAS components: angio-tensinogen, renin, angiotensin-converting enzyme (ACE), angiotensin II receptors (AT1 and AT2), as well as the components of the nonclassical pathway including ACE2 and MAS receptors for angiotensin (1-7).
Recently, a homologue of angiotensin converting enzyme (ACE), namely, ACE2 has been identified [6].
It does not appear to be associated with or dependent on the angiotensin converting enzyme 2 (ACE2) and angiotensin (1-7) (Ang(1-7)) axis [27], and despite known renal actions of AngII given at higher doses, we have repeatedly reported no chronic changes in sodium or water balance using this model of hypertension [17, 19, 21].
In high-dose STZ model, renal expression of RAS components was changed in a similar manner in STZ eNOS -/- and eNOS +/+ mice compared with nondiabetic counterparts as follows: (upregulated) angiotensinogen mRNA, ACE2, AT1 receptor, and MCR proteins, (downregulated) renin mRNA, and (unaltered) ACE protein.
Ability to efficiently use the receptor molecules (ACE2 for human and civet) seems to be a major limiting factor for animal-to-human and human-to-human transmission (35).
Ang-(1-7) is synthesized directly from Ang II or indirectly from Ang I by an ACE homolog enzyme (ACE2), which in turn binds into the Mas receptor [109, 110].
The S1 subunit is responsible for virus binding to the receptor, angiotensin-converting enzyme 2 (ACE2) (15,16).
The angiotensin-converting enzyme (ACE) converts Ang I to Ang II, whereas the angiotensin-converting enzyme 2 (ACE2) metabolizes Ang II and generates Ang-(1-7) [10].
To make the quail QT6/ACE2 cell line, the gene encoding the receptor for SARS-CoV, human angiotensin-converting enzyme 2 (ACE2) (35), was cloned from a human primary kidney cDNA library (Invitrogen, Paisley, Scotland, UK) using 21-mer primers designed to the start and stop of ACE2, and subcloned into pcdna3.1+.