ACE


Also found in: Dictionary, Thesaurus, Legal, Financial, Acronyms, Idioms, Encyclopedia, Wikipedia.

angiotensin

 (ACE) [an″je-o-ten´sin]
a vasoconstrictive substance formed in the blood when renin is released from the juxtaglomerular apparatus in the kidney. The enzymatic action of renin acts on angiotensinogen to form the decapeptide angiotensin I, which is relatively inactive. It in turn is acted upon by peptidases (converting enzymes), chiefly in the lungs, to form the octapeptide angiotensin II, a powerful vasopressor and a stimulator of aldosterone secretion by the adrenal cortex. By its vasopressor action, it raises blood pressure and diminishes fluid loss in the kidney by restricting blood flow. Angiotensin II is hydrolyzed in various tissues to form heptapeptide angiotensin III, which has less vasopressor activity but more effect on the adrenal cortex.
angiotensin-converting enzyme (ACE) an enzyme of the hydrolase class that catalyzes cleavage of a dipeptide from the C-terminal end of angiotensin I to form activated angiotensin II; called also peptidyl-dipeptidase A.
angiotensin-converting enzyme inhibitors competitive inhibitors of angiotensin-converting enzyme, which converts angiotensin I to angiotensin II and inactivates bradykinin. ACE inhibitors, such as captopril, are antagonists of the renin-angiotensin-aldosterone system and potentiators of the kinin system and are used for treatment of hypertension, usually in conjunction with a diuretic. They are also used as vasodilators in the treatment of congestive heart failure.

ACE

ACE

(1) Abciximab & Carbostent Evaluation in Acute Myocardial Infarction. A trial comparing outcomes of carbon-coated stenting of an infarct-related artery with and without abciximab.
Primary endpoint 30-day MACE (major acute coronary events)
Conclusion Abciximab + IRA stenting may be a viable reperfusion strategy in patients with acute myocardial infarction undergoing primary percutaneous revascularization.
(2) ASA & Carotid Endarterectomy. A trial comparing high- and low-dose aspirin to reduce the risk of stroke in patients undergoing carotid endarterectomy.
Primary endpoints 30-day MACE (major acute coronary events), stroke
Conclusion Low-dose (80, 325 mg) ASA patients did better

ACE

Angiotensin-converting enzyme, see there. Cf ACE inhibitors, also
1. Acute Care for Elderly.
2. Adriamycin, cyclophosphamide, etoposide.
3. Alcohol, chloroform, ether–obsolete anesthetic cocktail.
4. American College of Epidemiology.

ACE

Abbreviation for angiotensin-converting enzyme.

ACE

See ANGIOTENSIN-CONVERTING ENZYME.
References in periodicals archive ?
Jubilee Ace's launch event was held in Macau and primarily features what appears to be affiliates of Asian origin.
Nevertheless, we are vaulting ahead without the causal research to back up the primacy of the negative causal role of ACEs or about how ACEs interact with other factors.
While inaugurating the show flat, star designer Gauri Khan said, "I have been associated with the Ace Group for three years now and am impressed with their wide span of successful projects.
They said a number of PSS officers worked in ACE in the past efficiently.
Larkin: The Storm (7-4, 3-0) won 25-9, 25-9 behind Hayley Fisher (6 kills, 6 digs), Emily Wellman (13 digs), McKayla Geraghty (9 digs, 2 aces), Rylee Pompa (5 kills) and Anna Skrzpchak (9 assists).
There are two words that ACE doesn't use; 'can't' and 'won't'.
Caption: Richard McLaren, Chair of ACE Trustees 1994-2016
Based on the closing price of Ace stock on 30 June 2015, the total value is approximately USD 124.13 per Chubb share, or USD 28.3bn in the aggregate.
ACE members are engaged in all of these types of activities.
On June 28, 2012, further to the approval by ACE shareholders on April 25, 2012 of a special resolution providing for the voluntary liquidation of ACE, the Superior Court of Quebec issued an order appointing Ernst and Young Inc.
Details of the program, which is complimentary for new and current ACE Environmental Risk clients, including access to the online portal where ACE Environmental Risk clients can complete their enrollment, is available at https://ace.spillcenter.net/.
ACE Worldview is a virtual platform, first introduced in 2010, and is designed to meet the distinctive needs of multinational risk managers and their insurance brokers to enable them to monitor the status of their entire global program, obtain copies of local insurance policies and certificates, and access proprietary research tools.