ACADL


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ACADL

A gene on chromosome 2q34-q35 that encodes an acyl-CoA dehydrogenase which is a mitochondrial flavoenzyme involved in fatty acid and branched chain amino-acid metabolism. It is one of four enzymes that catalyse the first step of mitochondrial beta-oxidation of straight-chain fatty acid.

Molecular pathology
Defects of ACADL cause long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycaemia.
References in periodicals archive ?
Lipid metabolism: The following genes were categorized into the lipid metabolism pathway: PLTP (lipid transport); SCD (lipogenesis); liver X receptor a, nuclear receptor subfamily 1, group H, member (LR1H3) (cholesterol metabolism); FABP3 (fatty acid transport); CPT2, ACADL, and ACOX2 (fatty acid oxidation); and FABP4 (adipocyte differentiation).
2014) found that ACADL genes were positively correlated with the adipocyte volume.
The second contained ACOX2, CPT2, SCD, NR1H3, and ACADL.