ACADL


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ACADL

A gene on chromosome 2q34-q35 that encodes an acyl-CoA dehydrogenase which is a mitochondrial flavoenzyme involved in fatty acid and branched chain amino-acid metabolism. It is one of four enzymes that catalyse the first step of mitochondrial beta-oxidation of straight-chain fatty acid.

Molecular pathology
Defects of ACADL cause long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycaemia.
References in periodicals archive ?
2014) found that ACADL genes were positively correlated with the adipocyte volume.
Activation of PPARG promotes terminal differentiation through the induction of a range of genes important for TG formation through fatty acid oxidation among downstream pathways involving CPT2, ACADL, and ACOX2.
Genes encoding FA metabolic enzymes were also up-regulated: ACSL1, ACAA2, ACADL, ACADVL, and HADHA.