lopinavir

(redirected from ABT-378)
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lopinavir

 [lo-pin´ah-vir]
an HIV protease inhibitor, an antiviral agent used in combination with ritonavir in the treatment of human immunodeficiency virus infection; administered orally.

lopinavir

An antiretroviral protease inhibitor with potent anti-HIV effect in clinical studies.
 
Adverse effects
Headache, diarrhea.
References in periodicals archive ?
ABT-378. The limited oral bioavailability of this "small" protease inhibitor (PI) can be overcome when it is used with low-dose ritonavir (100-200 mg twice a day).
Researchers reported on several new drugs--such as ABT-378 from Abbott Laboratories and T-20 from Trimeris Inc.--that are showing strong potential.
For example, Abbott Laboratories has a new-generation protease inhibitor known as ABT-378 that in lab tests has shown itself to be more powerful than the protease inhibitors on the market.