ABO incompatibility

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Related to ABO incompatibility: Coombs test

ABO Incompatibility

A type of blood incompatibility in which recipients—e.g., those with genotypes AO, BO, OO—of donated blood products, usually understood to mean packed red cells, have antibodies to antigens A or B on the surface of red cells being transfused.

ABO incompatibility

Transfusion medicine A type of blood incompatibility, in which certain recipients–eg genotypes AO, BO, OO of donated blood products-usually understood to mean packed RBCs, has antibodies to antigens–A or B on the surface of RBCs being transfused. See ABO system.

ABO incompatibility

An antigen-antibody immune response to infusion of another's red blood cells. Transfusion reactions occur most commonly in people with type O blood, which carries no antigens on the red blood cells and contains both anti-A and anti-B antibodies. People with type A blood carry A antigens on their red cells and anti-B antibodies; those with type B blood carry B antigens and anti-A antibodies; those with type AB blood carry both A and B antigens but no antibodies to A or B. The antibodies are called natural antibodies because their formation does not require sensitization by A and B antigens. The antibodies recognize the antigens on the donor cells as foreign and destroy them by agglutination and lysis. ABO incompatibilities are different from Rh incompatibilities, which are most commonly related to the D antigen in the Rh blood group. See: table; blood group

Obstetrics: Transplacental fetal-maternal transfusion occurs when fetal blood cells escape into the maternal circulation, eliciting antibody formation. Maternal antibodies then cross the placenta into the fetal circulation, attack, and destroy red blood cells, as evidenced by neonatal hyperbilirubinemia and jaundice.

See also: incompatibility
References in periodicals archive ?
An early (sixth-hour) serum bilirubin measurement is useful in predicting the development of significant hyperbilirubinemia and severe ABO hemolytic disease in a selective high-risk population of newborns with ABO incompatibility.
12 There are over 60 RBC antigens that are responsible for an antigen antibody response, but the Rh group with its D antigen and ABO incompatibility remains the most significant cause of hemolysis in neonates.
The neonate ,whose bilirubin was high because of ABO incompatibility, had blood group A-ve, and that of mother's was B+ve & this baby was the second issue of the lady
Impact of ABO incompatibility on outcome after allogeneic peripheral blood stem cell transplantation.
You try adding in terms for the ABO incompatibility portion of the question from Table 1, but you notice that doing so seems to screen out quite a bit of material, leading you to suspect that you may be risking omitting relevant information, and you return to the broader search strategy.
4,5] It was concluded that screening for hemolytic disease due to ABO incompatibility was not cost-effective,[4] and the importance of clinical observation of the newborn was emphasized.
The most common risk factor associated was ABO incompatibility.
Efficacy of intensive blue double-lamp phototherapy in the treatment of ABO incompatibility and idiopathic severe hemolytic jaundice].
A study by Ashutosh Kumar et al similarly showed that ABO incompatibility was the leading cause of haemolysis (in 48%) followed by Rh incompatibility (in 22%), septicaemia in 26% and G6PD deficiency in 4%.
Blood groups are also known to have some association with diseases like duodenal ulcer, diabetes mellitus, urinary tract infection, Rh and ABO incompatibility of newborn.
Significant neonatal unconjugated hyperbilirubinemia can be caused by prematurity, ABO and RH incompatibility, G6PD deficiency, minor blood group incompatibility or idiopathic aetiology, of which ABO incompatibility is most common aetiology followed by the other causes.