autologous bone marrow transplantation

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autologous bone marrow transplantation

A procedure in which haematopoietic stem cells are extracted (apheresed) from a patient with lymphoma and other cancers, who is treated with high-dose chemo- and/or radiotherapy to eliminate malignant cells in the bone marrow. The stem cells are then administered. ABMT is a standard second-line therapy for some lymphomas; it has a low risk of infection and has no risk of graft-versus-host disease, which is typical of allogeneic bone marrow transplantation. ABMT is less preferred for patients with acute myeloid leukaemia, in whom the relapse may occur as the patient’s marrow may contain malignant cells.

autologous bone marrow transplantation

Transplantation medicine The administration to an individual 'X' of his/her own BM, often to a leukemic Pt in relapse who, because a suitable HLA-matched donor is not available, would otherwise die of the disease. See Bone marrow.

autologous bone marrow transplantation

Abbreviation: ABMT
The harvesting and preservation of a patient's own blood-forming cells, followed by their eventual reintroduction into a patient. The procedure may be used to treat a variety of cancers and blood disorders. Current practice is to mobilize stem cells into the blood stream with growth factors and then to collect and filter the blood by leukapheresis. In leukapheresis stem cells are identified by a cell surface antigen called CD34. After desirable blood-forming cells with this antigen are removed from the patient's blood, high-dose chemotherapy, monoclonal antibody therapy, or radiation may be used to purge the marrow of diseased cells. Healthy CD34+ cells capable of rebuilding the bone marrow are then returned to the patient and stimulated to reproduce. Synonym: autologous hematopoietic stem cell transplantation
See also: transplantation
References in periodicals archive ?
The treatment group received 4 weekly sessions of ABMT in addition to usual psychiatric care (consultations with psychiatrists and/or administration of psychiatric medication), whereas the control group received 4 weekly sessions of sham ABMT in addition to usual psychiatric care.
Patients receiving ABMT demonstrated considerable improvement in their laboratory data, with no procedure-related complications [16].
In its early days, ABMT for breast cancer was considered an investigative therapy by many payers, and thus considered ineligible for coverage.
A larger percentage of women are hearing such words since breast cancer has become the most common form of cancer among American women.(79) HDC-ABMT has become a last resort for many of these women, since their breast cancer has metastaticized, spreading all over their bodies.(80) "Many women believe that they have little to lose with ABMT and that it is the only reasonable approach in an otherwise hopeless situation."(81)
One widely cited study reviewed 533 breast cancer patients in clinical trials who requested coverage for ABMT from 1989 through 1992.
During this period in the early 1990s, technology assessment of the therapy was undertaken at a number of our collaborating managed care organizations and by the Medical Advisory Panel of the Blue Cross/Blue Shield Technology Evaluation Center (TEC).[4] The National Cancer Institute authorized four randomized clinical trials for ABMT in advanced breast cancer in 1991 (with support from TEC), but these results would not be available for some time.
Note that it could have been the case ten years ago that this woman was part of a pool of one thousand women in a large corporation who, in order to control their escalating health insurance premiums, agreed among themselves that it was a better buy, all things considered, for each and every member of that group to cover screening mammograms instead of ABMT. This is Eddy's Patient.
While still a concern, the first two ABMT transactions in 2016 have shown improved geographic diversification compared with those in 2015.
Western Union and Bank Albilad have signed an agreement to launch Western Union's Account-Based Money Transfer (ABMT) service for the first time in the Kingdom
Western Union, a leader in global payment services and Emirates NBD, a leading bank in the region, have signed an agreement to launch Western Union's account-based money transfer (ABMT) service for the first time in the UAE.
Western Union is to launch its Account-Based Money Transfer (ABMT) service in early 2011.