ABL1

ABL1

A gene on chromosome 9q34.1 that encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, cell division, cell adhesion and stress response. ABL1 is negatively regulated by its SH3 domain.

Molecular pathology
Deletion of the SH3 domain turns ABL1 into an oncogene; the t(9;22) translocation results in the head-to-tail fusion of BCR and ABL1, which is present in many cases of CML.
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(20.) Branford S, Yeung T, Parker WT, Roberts ND, Purins L, Braley JA, Prognosis for patients with CML and > 10% Bcr Abl1 after 3 months of imatinib depens on the rate of Bcr Abl1 decline.
Inclusion criteria were: 18 years or older, diagnosed with CML in CP with positive BCR ABL1. Patients who were in accelerated/blast phase, or already taking any Tyrosine Kinase Inhibitors or chemotherapy were excluded from the study.
To the Editor: The t(9;22)(q34;q11) (Philadelphia chromosome [Ph]) balanced translocation results in fusion of the BCR gene at 22q11 with cytoplasmic tyrosine kinase gene ABL1 and plays an essential role in leukemic transformation.
Another set of patients demonstrate translocation involving tyrosine kinases, such as ABL1 (with genes other than BCR), ABL2, PDGFRB, NTRK3, TYK2, CSF1R, and JAK2.
(8) Assays were run in triplicate on the ABI 7900 platform (Thermo Fisher Scientific), and mutated transcript levels were compared with expression of the ABL1 reference gene using plasmid standards (Qiagen).
ETV6 is genetically unstable and fuses not only with NTRK3 but also with other genes, including ABL1, EGFR3, PAX5, SYK and JAK2 in leukaemia, myelodysplastic syndromes, and sarcomas (7).
The BCR-ABL1 fusion protein provides additional regulatory binding domains contained within BCR to the ABL1 tyrosine kinase, which increases the number of potential targets for the kinase [16].
FISH analysis for the BCR and ABL1 regions can detect almost all variants of this rearrangement.
pylori are associated with cell cycle progression and proliferation (p14, p16, p21, p27, RAB40C, COX 2, FOS, ERBB2, FGFR2, ABL1, ECOP, JAK2, MYC, MET, SIRT1, PDCD4, TRAF6, GMNN, and CCNE2) [213, 223-242], apoptosis (RECK, SMAD4, TRAIL, MCL1, BIM, XIAP, and PDK1) [243-250], and invasion and metastasis (pTEN, WNT 5a, EDNRA, ROR2, EPB41L3, MMP1, MMP10, HMGA2, ROBO1, TGF-[beta], EZH2, casein kinase 2, and ZEB) [251-262].
(vi) The cytoplasm (location tag CLc) contains enzyme Pi3k and some proteins, Abl1, Akt1, Araf, ArhGap5, and so forth.
Gomez de Cedron et al., "Genetic and epigenetic silencing of MicroRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression," Cancer Cell, vol.