ABHD6

ABHD6

A gene on chromosome 3p14.3 that encodes a protein that is thought to have 2-arachidonoylglycerol hydrolase activity and regulate endocannabinoid signalling pathways.
References in periodicals archive ?
Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6.
91) ABHD6 acts as lysophospholipase or monoacylglycerol lipase, the latter being possibly related to the regulation of 2-arachidonoyl glycerol (2-AG) signaling.
2010) The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors.
2013) The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.
These researchers said that "an ideal drug for type-2 diabetes would increase insulin levels in blood by enhancing the beta cells response to glucose only when it is elevated and also increase the sensitivity of body tissues to insulin; this is precisely what ABHD6 inhibition does and thus we have identified a unique new target for type 2 diabetes.
38)) Since MGL and ABHD6 display different distribution patterns, the former being presynaptic and the latter being postsynaptic (Fig.
Postsynaptic COX-2 and ABHD6 may also contributes to inactivation of 2-AG.
9]-Tetrahydrocannabinol; 2AG: 2-arachidonoylglycerol; ABHD6 and ABHD12: [alpha]/[beta] hydrolase domain 6 and 12; CCK: cholecystokinin; COX-2: cyclooxygenase-2; CaER: [Ca.