ABCG2


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ABCG2

A gene on chromosome 4q22, which encodes a xenobiotic transporter protein of the ATP-binding cassette (ABC) superfamily, White subfamily. It plays a major role in multi-drug resistance to chemotherapeutics, and is highly expressed in the placenta, but its role there is unknown.
References in periodicals archive ?
Other studies have identified a minor population of melanoma cells with enhanced tumorigenic potential that stains positively for CD133 or the ABC transporter protein ABCG2, (121) or have identified a side population by using the flow cytofluorimetric technique based on heightened capacity of stem cells to efflux fluorescent dyes.
WPE-stem cells also highly express the prostate SC markers ABCG2 [ATP-binding cassette, subfamily G (WHITE), member 2] and BMI-1 [BMI1 polycomb ring finger oncogene] [see Supplemental Material, Figure 1, available online (doi: 10.1289/ehp.0901059.
Ozawa et al., "ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells," Scientific Reports, vol.
Watchko, "ABC transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ ABCG2) expression in the developing human CNS," Neuropediatrics, vol.
Apart from the low-level cross-resistance of HCT-116 [p53.sup.-/-] cells to reserpine compared to wild-type HCT-116 [p53.sup.+/+] cell, the pother drug-resistant cell lines overexpressing ABCB1, ABCG2, or EGFR did not reveal cross-resistance to reserpine.
Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle.
The ATP-binding cassette transporter ABCG2, a member of the ABC transporters, has been proposed as a potential marker of a wide variety of stem cells including limbal stem cells [23, 38], since it is expressed in certain basal cells of human corneal limbus and absent in the suprabasal layer as well as in the central corneal epithelium.
Intracellular S1P can be exported by several transporters, such as the ATP-binding cassette transporters ABCA1 [34], ABCC1 [35, 36], and ABCG2 [36] and spinster 2 (SPNS2) [37-39].
miRNAs downregulated in chemoresistance to conventional drugs miR-22 5-FU BTG1 miR-34a 5-FU SIRT1, E2F3, KIT, LDHA miR-122 5-FU PKM2 miR-129 5-FU BCL2, TYMS, E2F3 miR-133a Oxaliplatin RFFL miR-139-5p 5-FU NOTCH1 miR-141/200c Oxaliplatin ZEB1 miR-143 5-FU, oxaliplatin BCL2, NFKB, ERK5, IGF1R miR-145 5-FU FLI-1, RAD18 miR-149 5-FU FOXM1 miR-153 Oxaliplatin FOXO3 miR-196a Oxaliplatin HOXA7, HOXB8, HOXC8, HOXD8 miR-200 cluster 5-FU EMT-related genes miR-203 5-FU TYMS miR-204 5-FU HMGA2 miR-222 Oxaliplatin ADAM17 miR-297 Oxaliplatin ABCC2 miR-451 Irinotecan ABCC1 miR-497 5-FU, irinotecan IGF1R miR-519c 5-FU, oxaliplatin ABCG2, ELAVL1 (HuR) miR-1915 Oxaliplatin BCL2 miRNAs overexpressed in chemoresistance to monoclonal antibody-based therapies miR-17-3p Cetuximab ?
Huan et al., "Hypoxia-inducible factor-2a is associated with ABCG2 expression, histology-grade and Ki67 expression in breast invasive ductal carcinoma," Diagnostic Pathology, vol.
Ieiri, "Functional significance of genetic polymorphisms in P-glycoprotein (MDR1, ABCB1) and breast cancer resistance protein (BCRP, ABCG2)," Drug Metabolism and Pharmacokinetics, vol.