The channel contains a regulatory subunit, composed of the ABCC8 or ABCC9 (ATP-binding cassette, subfamily C members 8 and 9) gene products referred to as sulfonylurea receptor 1 and 2 (SUR1 and SUR2) proteins , respectively.
Zhang et al., "ABCC8 and ABCC9: ABC transporters that regulate K+ channels," Pflugers Archiv, vol.
Adomaviciene et al., "Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9
," International Journal of Cardiology, vol.
Specific genetic risk factors have been linked to HS-aging pathology, including gene variants of progranulin (GRN), (19) transmembrane protein 106B (TMEM106B), (12) ATP-binding cassette, subfamily C member 9 (ABCC9), (14) and potassium calcium-activated channel subfamily M regulatory [beta] subunit 2 (KCNMB2).
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
Among those, we selected, for the microarray and RNA-seq analyses, four PG transporters, ABCC1 (also known as MRP1), ABCC9 (also known as sulfonylurea receptor 2 [SUR2]), SLCO4C1 (also known as OATP4C1), and SLCO5A1 (also known as OATP5A1), because these have been shown to be differentially expressed in the uterine endometrium during early pregnancy [10,11].
ABCC9 is a subunit of ATP-sensitive [K.sup.+] channel and is expressed in many tissues including myometrium, cardiac and skeletal muscle .
Experts found those with the gene ABCC9
need around 30 minutes more sleep per night than those without it.
The other subunits of this channel namely [K.sub.IR]6.1 and SUR2 are coded by the genes KCNJ8 and ABCC9
Expression of Abcc9
and Nppb were upregulated in GK compared to control SAN.
Karla Allebrandt and her team from the Ludwig Maximilians University of Munich identified a gene called ABCC9
that can reduce the length of time we sleep.
Insulin secretion from pancreatic beta cells can be modulated by a complex cluster of proteins encoded by related genes, including KCNJ11, ABCC8, voltage-sensitive calcium channels (VSCCs), ABCC9
, protein kinase catalytic subunit G (PRKACG), rap guanine nucleotide exchange factor 4 (RAPGEF4), forkhead box A2 (FOXA2), and endosulfine alpha (ENSA).