ABCC5


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ABCC5

A gene on chromosome 3q27 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC5 exports its substrate, cyclic nucleotides, contributing to the degradation of phosphodiesterases, and may be an elimination pathway for cyclic nucleotides. ABCC5 is linked to resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, in patients with acute lymphocytic leukaemia, and resistance to antiretroviral nucleoside analogues (e.g., 9-(2-phosphonylmethoxyethyl)adenine) in HIV-infected patients.
References in periodicals archive ?
[27] Apart from that, a various subfamily of ATP-binding cassette (ABC) is responsible for pumping out doxorubicin, including ABCB1, ABCB5, ABCB8, ABCC5, and ABCG2.
Another study in patients who were treated with gemcitabine before surgery showed that two SNPs in ABCC2 and ABCC5 were associated with overall survival, and the ABCC2 G40A GG genotype was associated with poor histological response to gemcitabine [14].
Luminal [25] Abluminal [24, 25] MRP5 (ABCC5) Yes [24, 27] ?