MRP4 (gene ABCC4
) is an inducible basolateral transporter that cotransports taurine and glycine conjugates of cholic acid with glutathione.
found that ABCC4
gene polymorphisms were associated with susceptibility to KD in European populations in a family-based linkage study performed using a cohort of 1284 KD subjects and their family members (a total of 3248 individuals) .
In our earlier study, we have shown that PG transporters such as ATP-binding cassette, subfamily C, member 4 (ABCC4
; also known as multidrug resistance protein 4 [MRP4]) and solute carrier organic anion transporter family, member 2A1 (SLCO2A1, also known as PG transporter [PGT] or organic anion-transporting polypeptide 2A1 [OATP2A1 ]), are expressed in the uterine endometrium during early pregnancy in pigs .
Two mutations in AKR1C1 p.Arg170His and RXRA p.Pro22Leu, genes involved in bile acid metabolism (according to the Reactome databases), were found in patient number 5, and a mutation in ABCC4
p.Lys304Asn, a gene involved in bile acid transport and secretion, was uncovered in patient number 6 (Table 3 B, C).
Hypoxia/reoxygenation (H/R) stress can induce the upregulation of the mRNA expression of Abcc1, Abcc2, and Abcc4
at the BBB.
Multidrug resistance protein 4 (ABCC4
) is a member of the family of ATP-binding cassette transporters required for the active transport of many bioactive substrates across the cell membrane .
Fukuda et al., "The ABCC4
membrane transporter modulates platelet aggregation," Blood, vol.
Both organic anions and xenobiotics in the blood use the same organic anion transporters (OATs) for entry into proximal tubule cells and they then exit these cells through ATP dependent ABCC2 (MRP2) and ABCC4
(MRP4), cassette transporters located at the luminal membrane of the cells (Sekine et al., 2006).
ABCC1 HsOD219905_ml 16.75 (0.13) ABCC2 Hs00166123_ml 19.57 (0.81) ABCC3 Hs0035B656_ml 16.72 (0.47) ABCC4
Hs00195260_ml 16.80 (0.24) ABCC5 Hs00194701_m1 19.72 (0.16) ABCC6 Hs00184566_m1 19.90 (0.52) ABCC7 Hs00357011_ml n.e.
Quantitative florescent amplification of cDNA of ABCC1 (Hs01561502_m 1), ABCC3 (Hs00978473_ml), and ABCC4
(Hs00988717_m1) was performed using TaqMan Gene Expression Assays (Applied Biosystems, CA).
evaluated a role of the ABCC4
gene polymorphism in airway inflammation of asthmatics.