ABCC2

ABCC2

A gene on chromosome 10q24 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC2 is found in the canalicular (apical) part of hepatocytes and involved in biliary transport. Its substrates include chemotherapeutics (e.g., vinblastine) and thus contributes to drug resistance in humans.
 
Molecular pathology
ABCC2 is mutated in patients with Dubin-Johnson syndrome.
References in periodicals archive ?
21), confirmed that miR-490-3p enhanced cisplatin sensitivity of ovarian cancer cells through down-regulating ABCC2 expression.
Another resistance gene was mapped to the locus of an ABCC2 transporter gene (Park et al.
sup][1] Dubin-Johnson syndrome (DJS, MIM #237500) is characterized by fluctuating mild, predominantly conjugated hyperbilirubinemia and is caused by mutations in the ATP-binding cassette subfamily C member 2 gene ( ABCC2 ).
Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients.
Polymorphisms in the human ABCC2 gene, which encodes MRP2, are associated with variations in urinary excretion of [Hg.
Characterisation of the roles of ABCB1 ABCC1 ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo.
Association between ABCC2 gene haplotypes and tenofovir-inducedproximal tubulopathy.
El gen ABCC2 codifica para el MRP2 y 2 pequenos estudios han sugerido una posible asociacion entre el haplotipo ABCC2 y el riesgo de toxicidad por exposicion a TDF.
Genetic polymorphisms in CYP3A5, CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4), MDR1, UGT1A9, ABCC2 [ATPbinding cassette, sub-family C (CFTR/MRP), member 2; formerly known as MRP2], and TPMT (thiopurine S-methyltransferase) have an impact on tacrolimus, MPA, and azathioprine metabolism and transport, respectively.
Effect of the ATP- binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/-(triple-knockout) and wild-type mice.
Both organic anions and xenobiotics in the blood use the same organic anion transporters (OATs) for entry into proximal tubule cells and they then exit these cells through ATP dependent ABCC2 (MRP2) and ABCC4 (MRP4), cassette transporters located at the luminal membrane of the cells (Sekine et al.
Background: Placental multidrug resistance-associated protein 2 (MRP2), encoded by ABCC2 gene in human, plays a significant role in regulating drugs' transplacental transfer rates.