ABCC2

ABCC2

A gene on chromosome 10q24 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC2 is found in the canalicular (apical) part of hepatocytes and involved in biliary transport. Its substrates include chemotherapeutics (e.g., vinblastine) and thus contributes to drug resistance in humans.
 
Molecular pathology
ABCC2 is mutated in patients with Dubin-Johnson syndrome.
References in periodicals archive ?
Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.
MiR 490 3p sensitizes ovarian cancer cells to cisplatin by directly targeting ABCC2. Am J Transl Res.2017;9:1127-38.
MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid.
(21), confirmed that miR-490-3p enhanced cisplatin sensitivity of ovarian cancer cells through down-regulating ABCC2 expression.
Likewise, FXR can directly transactivate the ABCC2, ABCB4, and SLCO1B3 genes [36, 37].
ATX-LPA axis has been shown to induce chemoresistance by upregulating antioxidant genes, multidrug-resistant transporters (ABCC1, ABCG2, ABCC2, and ABCC3), aldehyde dehydrogenase 1 (ALDH1), and stem cell maintenance [99, 136].
Day, "Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes," Gastroenterology, vol.
Another resistance gene was mapped to the locus of an ABCC2 transporter gene (Park et al.
Moreover, some ABC transporter genes, such as ABCB1, ABCA12, ABCA5, ABCA3, ABCC2, ABCC5, and ABCC6, were strongly upregulated in CTC-MCC-41 compared with HT-29 cells.
[sup.99m]Tc-MIBI is a substrate for PGP (P-glycoprotein, gene symbol ABCB1), MRP1 (multidrug resistance protein 1 (gene symbol ABCC1)), and MRP2 (multidrug resistance protein 2 (gene symbol ABCC2)) and can be used to image their expression in vivo [19].
Hypoxia/reoxygenation (H/R) stress can induce the upregulation of the mRNA expression of Abcc1, Abcc2, and Abcc4 at the BBB.
These downstream genes encode (1) antioxidant enzymes such as [gamma]-glutamate cysteine ligase catalytic subunit (GCLC) and regulatory subunit (GCLM), (2) phase II drug-metabolizing enzymes such as heme oxygenase 1 (HMOX1) and NAD(P)H quinone oxidoreductase 1 (NQO1), and (3) multidrug-resistant proteins (MRPs) such as ATP-binding cassette subfamily (ABC) C1 (ABCC1), ABCC2, ABCC3, and ABCG2 [18-20].