ABCC1


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ABCC1

A gene on 16p13.1 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC1 is a transporter of multispecific organic anions, glucuronides and sulfate conjugates of steroid hormones and bile salts; it mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, methotrexate, antivirals and other xenobiotics, and confers resistance to anticancer drugs.
References in periodicals archive ?
ABCB1 was mainly expressed by cells in the [CD45.sup.+] subpopulation while ABCC1 was expressed in both subpopulations [29].
Only ADAM17 and ABCC1 were significantly differentially expressed in NR or ONR without stratifying them into CTC+/-.
Although it has been shown that expression of ABCC1 gene is induced by estrogen and progesterone in human trophoblast cells [18], regulatory mechanisms of the expression of PG transporter genes, ABCC1, ABCC9, SLCO4C1, and SLCO5A1 are not well understood.
Cole, "Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1)," The Journal of Biological Chemistry, vol.
ABCBl, ABCC1 and ABCG2 mRNA expression levels were quantified by real-time RT-PCR as described previously (Teng et al.
Specifically, the genetic polymorphisms of ABCB1, ABCC1, and ABCG2 in both normal and pancreatic cancerous specimens were analyzed.
Leiber, "ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium," Cellular Signalling, vol.
And in the recent study the researchers identified common variants at the beginning and end of the ABC1 and ABCC1 genes.
It was located on ABCC1, the efflux carrier gene, which codes for a protein serving as a pump that removes MTX from the cell.
These downstream genes encode (1) antioxidant enzymes such as [gamma]-glutamate cysteine ligase catalytic subunit (GCLC) and regulatory subunit (GCLM), (2) phase II drug-metabolizing enzymes such as heme oxygenase 1 (HMOX1) and NAD(P)H quinone oxidoreductase 1 (NQO1), and (3) multidrug-resistant proteins (MRPs) such as ATP-binding cassette subfamily (ABC) C1 (ABCC1), ABCC2, ABCC3, and ABCG2 [18-20].
Furthermore, Saeed and colleagues further documented an association between high ABCC1 expression and resistance to the two glycosides could not be established in the NCI cell line, and they concluded that ABC transporter had a limited role in the unresponsiveness of NCI cell line to acovenoside A and ouabain [156].
miRNAs downregulated in chemoresistance to conventional drugs miR-22 5-FU BTG1 miR-34a 5-FU SIRT1, E2F3, KIT, LDHA miR-122 5-FU PKM2 miR-129 5-FU BCL2, TYMS, E2F3 miR-133a Oxaliplatin RFFL miR-139-5p 5-FU NOTCH1 miR-141/200c Oxaliplatin ZEB1 miR-143 5-FU, oxaliplatin BCL2, NFKB, ERK5, IGF1R miR-145 5-FU FLI-1, RAD18 miR-149 5-FU FOXM1 miR-153 Oxaliplatin FOXO3 miR-196a Oxaliplatin HOXA7, HOXB8, HOXC8, HOXD8 miR-200 cluster 5-FU EMT-related genes miR-203 5-FU TYMS miR-204 5-FU HMGA2 miR-222 Oxaliplatin ADAM17 miR-297 Oxaliplatin ABCC2 miR-451 Irinotecan ABCC1 miR-497 5-FU, irinotecan IGF1R miR-519c 5-FU, oxaliplatin ABCG2, ELAVL1 (HuR) miR-1915 Oxaliplatin BCL2 miRNAs overexpressed in chemoresistance to monoclonal antibody-based therapies miR-17-3p Cetuximab ?