ABCB8

A gene on chromosome 7q36 that encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins, MDR/TAP subfamily, which is involved in multi-drug resistance as well as antigen presentation. It may be involved in the compartmentalisation and transport of heme and peptides, from the mitochondria to the nucleus and cytosol, and transport of phospholipids into mitochondrial membranes.

References in periodicals archive ?

27] Apart from that, a various subfamily of ATP-binding cassette (ABC) is responsible for pumping out doxorubicin, including ABCB1, ABCB5, ABCB8, ABCC5, and ABCG2.

A comparison between liposomal and nonliposomal formulations of doxorubicin in the treatment of cancer: an updated review

In addition, mice with heart-specific deletion or overexpression of ABCB8, which exports iron out of the mitochondria, were more sensitive or resistant, respectively, to DOX cardiotoxicity [52].

Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects

ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome.