ABCB6


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Related to ABCB6: ABCC6

ABCB6

A gene on chromosome 2q36 that encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins, MDR/TAP subfamily, which is involved in multi-drug resistance as well as antigen presentation, and thought to play a role in mitochondrial function.

Molecular pathology
ABCB6 is a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.
References in periodicals archive ?
The exons, splicing sites and 10 bp flanking intron sequences of ADAR1 and ABCB6 genes were captured by a gene chip commercially ordered from NimbleGen (Roche NimbleGen, Madison, WI, USA).
[sup][4] Clean reads (in FASTQ format) were aligned to the reference human genomic sequence (NCBI37/gh19) of ADAR1 and ABCB6 genes by using BWA software package (Burrows Wheeler Aligner, http://www.sourceforge.net/projects/bio-bwa/).
Some genes are relevant in the context of MDR, such as: CYP3A4, GSTP1, NR112 (PXR), 7XNRD1, ABCG2 (BCRP1), ABCB6, UBC, CYP1A1, ABCB1 (P-gp), CASP-3, and CASP-8.