ABCB5


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ABCB5

A gene on chromosome 7p21.1 that encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins, which participates in ATP-dependent transmembrane transport of a range from small ions, sugars and peptides to complex biomolecules.

Molecular pathology
The ABCB5 protein product is responsible for the doxorubicin resistance in some malignant melanomas.
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CSC Marker Function Glioma CD 49f Cell adhesion Ovary CD 117 SC-factor receptor Liver CD 13 Kidney disease marker Lung CD 56 Cell adhesion Renal CD105 Co-receptor TGF-[beta] Neuroblastoma CD 114 Colony stimulating factor 3 receptor Gastric CD 54 Cell adhesion Leukaemia TIM-3 Immune checkpoint receptor CD 96 T-cell specific receptor CD 9 Cell adhesion Breast CD 55 Complement inhibitor Melanoma CD 20 B-cell lineage ABCB5 ABC transporter Table 3: Cancer and TPDT.
Several cell surface markers have been verified to identify CSC-enriched populations, such as CD133, CD24, CD44, EpCAM (epithelial cell adhesion molecule), THY1, ABCB5 (ATP-binding cassette B5), and CD200 [27, 32, 34, 52].
Gene prioritization was conducted for genes in which recessive homozygous potentially deleterious variants were present, but the top five genes after prioritization, ABCB5, SKD2, DUS3L, HDAC10, and LMF2, have no direct link to liver function or bile acid metabolism as far as we know (Supplementary Material Online, Table S3).
The use of several cell-surface markers, such as CD44, CD24, CD133, CD166, EpCAM (epithelial cell adhesion molecule), and ABCB5 (ATP-binding cassette subfamily B member 5), has successfully allowed the isolation of CSCs from solid tumors, including human colon, breast, brain, pancreatic, liver, ovarian, and melanoma.
[27] Apart from that, a various subfamily of ATP-binding cassette (ABC) is responsible for pumping out doxorubicin, including ABCB1, ABCB5, ABCB8, ABCC5, and ABCG2.
Recently, we described another lignan, (-)-sesamin, whose cytotoxicity is not curtailed by both P-glycoprotein and its close relative, ABCB5 (Saeed et al., 2014).
In a collaborative effort between a number of institutions in Massachusetts, US, researchers uncovered that LSCs express a molecule called ABCB5 which plays a role in maintaining the population of LSCs in the eye, keeping them in a 'resting' state by avoiding programmed cell-death.
BOSTON, Mass., July 2, 2014 -- Researchers here have identified a way to enhance regrowth of human corneal tissue to restore vision, using a molecule known as ABCB5 that acts as a marker for hard-to-find limbal stem cells.
BOSTON, Mass., July 2, 2014 -- Researchers here have identified a way to enhance regrowth of human comeal tissue to restore vision, using a molecule known as ABCB5 that acts as a marker for hard-to-find limbal stem cells.
Washington, July 3 ( ANI ): Scientists have discovered a way to regrow human corneal tissue using hard-to-find limbal stem cells known as ABCB5 molecule.
High ABCB5 expression has shown to be associated with OSCC progression and recurrence making it a possible prognostic factor [50].
One recent finding that is further suggestive of tumorigenic heterogeneity within the melanoma VGP is the discovery by researchers within the laboratory of Markus Frank, MD (Children's Hospital, Boston, Massachusetts), of a defined subpopulation of human melanoma cells that express the multidrug resistance transporter known as adenosine triphosphate-binding cassette subfamily B (ABCB5; Figure 3, A and B).