TAP1

(redirected from ABCB2)

TAP1

A gene on chromosome 6p21.3 that encodes a member of the MDR/TAP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which plays a role in multidrug resistance. TAP1 pumps degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment.

Molecular pathology
TAP1 mutations have been tentatively linked to ankylosing spondylitis, type 1 diabetes and coeliac disease.
References in periodicals archive ?
Design of small molecule modulators for other disease-relevant ABC protein targets (e.g., CFTR/ABCC7, TAP1/ ABCB2, and TAP2/ABCB3; Table 1) could also be facilitated once biophysical methodologies enable more efficient characterization of these polytopic and highly dynamic membrane proteins.
The impact of SNPs in the ATP-binding cassette transporters ABCB1 and ABCB2 on the efficacy of mitoxantrone was examined retrospectively in 155 patients with MS [69].
To the best of our knowledge, the main products of this gene are two, ABCB1 and ABCB2, but only the first one confers multidrug resistance [49].