ABCB1

A gene on chromosome 7p21.12, which encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane protein. It is an ATP-dependent efflux pump for xenobiotics with broad substrate specificity, and functions as a transporter in the blood-brain barrier.

Molecular pathology
The ABCB1 protein product is responsible for reducing drug loads in multi-drug-resistant cells, thereby mediating resistance to anti-cancer drugs.

ABCB1

Member 1 of the B subfamily of ABC TRANSPORTER PROTEINS. Also known as MDR1. Polymorphism of the gene for ABCB1 is associated with multi-drug resistance in the treatment of a range of diseases including epilepsy, various cancers, rheumatoid arthritis and inflammatory bowel disease. Clinical experience has shown that several drugs used to treat cancer may become ineffective simultaneously in spite of having unrelated chemical structure. This multi-drug resistance was shown to be due to enhanced expression of ABCB1 which was using ATP-derived energy to export drugs from the cytosol to the extracellular fluid.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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We can finally conclude that in this population the response of individuals to ondansetron seems to be affected by ABCB1 gene C3435T polymorphism.

THE IMPACT OF ABCB1 (C3435T) POLYMORPHISM ON THE EFFICACY OF ONDANSETRON FOR POST-OPERATIVE NAUSEA AND VOMITING IN PAKISTANI POPULATION

Specific ABCB1 variants and DRD2 genetic polymorphisms (simultaneous occurrence of [greater than or equal to] 2 genetically determined phenotypes) might determine the dosage requirements of methadone.

What clinicians need to know about treating opioid use disorder: choose medication and non-medication options to fight abuse and relapse

Results: Among the tested ABC efflux transporters, [beta]-carotene significantly inhibited human P-gp efflux function without altering ABCB1 mRNA expression.

[beta]-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function

P-glycoprotein (P-gp) is an efflux transporter encoded by the ABCB1 (also known as MDR1) gene that protects the brain against neurotoxicants [66].

Genetic profile, environmental exposure, and their interaction in Parkinson's disease

Cyclosporine and tacrolimus (CNI) are known to be a substrate of cytochrome P450 (CYP) 3A5 and P-glycoprotein (P-gp), which are encoded by CYP3A5 gene and ATP-binding cassette subfamily B member 1 (ABCB1) gene, also known as multidrug-resistant gene 1 (MDR1), respectively (15,16,17,18).

Neurological complications after renal transplantation: a retrospective clinical study

Genotyping analyses of ABCB1 C3435T ABCG2 C421A and ABCC3 C-211T were conducted using the TaqMan methodology.

Effect of ABCB1 polymorphism on the clinical outcome of osteosarcoma patients after receiving chemotherapy

Of the 49 human ABC transporters, 15 are implicated in conferring resistance to chemotherapeutic agents in various cancers, and the most intensively characterized members are multidrug resistance 1 (MDR1 or P-glycoprotein, ABCB1), multidrug resistance protein 1 (MRP1, ABCC1), and breast cancer resistance protein (BCRP, ABCG2) [7].

ATP-binding cassette genes genotype and expression: a potential association with pancreatic cancer development and chemoresistance?

Impact of genetic polymorphisms in ABCB1, CYP2B6, OPRM1, ANKK1 and DRD2 genes on methadone therapy in Han Chinese patients.

Advances in genetic studies of substance abuse in China

Ieiri, "Functional significance of genetic polymorphisms in P-glycoprotein (MDR1, ABCB1) and breast cancer resistance protein (BCRP, ABCG2)," Drug Metabolism and Pharmacokinetics, vol.

Absorption and metabolism characteristics of rutin in Caco-2 cells

ABC transporter BBB BSCB Localization in (gene) brain capillary endothelium P-gp (ABCB1) Yes [24] Yes[35] Luminal [25] MRP1 (ABCC1) Yes [24, 25, 40] Yes[40] Luminal [25] Abluminal [24] MRP2 (ABCC2) Yes [24, 27] Yes[35] Luminal [25] MRP3 (ABCC3) Yes [24] ?

Neurovascular unit in chronic pain

Is a key transporter in the disposition of drugs in the CNS, some polymorphisms of ABCB1 gene, which encodes P-gp, produce a poor transporter that modifies the distribution of psychoactive drugs in the CNS and other tissues (8) ; (g) CYP2B6 enzyme.

Variantes geneticas asociadas con conducta adictiva en colombianos adictos y no adictos a heroina o cocaina

2008), both phase II DME genes; ABCB1 [ATP-binding cassette, subfamily B, member 1; also named multidrug resistance 1 (MDR1)] (Tang et al.

Molecular population genetics of human CYP3A locus: signatures of positive selection and implications for evolutionary environmental medicine

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