We can finally conclude that in this population the response of individuals to ondansetron seems to be affected by ABCB1
gene C3435T polymorphism.
variants and DRD2 genetic polymorphisms (simultaneous occurrence of [greater than or equal to] 2 genetically determined phenotypes) might determine the dosage requirements of methadone.
Results: Among the tested ABC efflux transporters, [beta]-carotene significantly inhibited human P-gp efflux function without altering ABCB1
P-glycoprotein (P-gp) is an efflux transporter encoded by the ABCB1
(also known as MDR1) gene that protects the brain against neurotoxicants .
Cyclosporine and tacrolimus (CNI) are known to be a substrate of cytochrome P450 (CYP) 3A5 and P-glycoprotein (P-gp), which are encoded by CYP3A5 gene and ATP-binding cassette subfamily B member 1 (ABCB1
) gene, also known as multidrug-resistant gene 1 (MDR1), respectively (15,16,17,18).
Genotyping analyses of ABCB1
C3435T ABCG2 C421A and ABCC3 C-211T were conducted using the TaqMan methodology.
Of the 49 human ABC transporters, 15 are implicated in conferring resistance to chemotherapeutic agents in various cancers, and the most intensively characterized members are multidrug resistance 1 (MDR1 or P-glycoprotein, ABCB1
), multidrug resistance protein 1 (MRP1, ABCC1), and breast cancer resistance protein (BCRP, ABCG2) .
Impact of genetic polymorphisms in ABCB1
, CYP2B6, OPRM1, ANKK1 and DRD2 genes on methadone therapy in Han Chinese patients.
Ieiri, "Functional significance of genetic polymorphisms in P-glycoprotein (MDR1, ABCB1
) and breast cancer resistance protein (BCRP, ABCG2)," Drug Metabolism and Pharmacokinetics, vol.
ABC transporter BBB BSCB Localization in (gene) brain capillary endothelium P-gp (ABCB1
) Yes  Yes Luminal  MRP1 (ABCC1) Yes [24, 25, 40] Yes Luminal  Abluminal  MRP2 (ABCC2) Yes [24, 27] Yes Luminal  MRP3 (ABCC3) Yes  ?
Is a key transporter in the disposition of drugs in the CNS, some polymorphisms of ABCB1
gene, which encodes P-gp, produce a poor transporter that modifies the distribution of psychoactive drugs in the CNS and other tissues (8) ; (g) CYP2B6 enzyme.
2008), both phase II DME genes; ABCB1
[ATP-binding cassette, subfamily B, member 1; also named multidrug resistance 1 (MDR1)] (Tang et al.