ABCB1

ABCB1

A gene on chromosome 7p21.12, which encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane protein. It is an ATP-dependent efflux pump for xenobiotics with broad substrate specificity, and functions as a transporter in the blood-brain barrier.

Molecular pathology
The ABCB1 protein product is responsible for reducing drug loads in multi-drug-resistant cells, thereby mediating resistance to anti-cancer drugs.

ABCB1

Member 1 of the B subfamily of ABC TRANSPORTER PROTEINS. Also known as MDR1. Polymorphism of the gene for ABCB1 is associated with multi-drug resistance in the treatment of a range of diseases including epilepsy, various cancers, rheumatoid arthritis and inflammatory bowel disease. Clinical experience has shown that several drugs used to treat cancer may become ineffective simultaneously in spite of having unrelated chemical structure. This multi-drug resistance was shown to be due to enhanced expression of ABCB1 which was using ATP-derived energy to export drugs from the cytosol to the extracellular fluid.
References in periodicals archive ?
ABCB1, ATP-binding cassette sub-family B member 1; TP, adenosine triphosphate; CNS, central nervous system; CYP, cytochrome P450 enzyme; OCT2, organic cation transporter 2; PPIs, proton pump inhibitors.
Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta.
Concise review: clinical relevance of drug-drug and herb-drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein).
The majority of the evidence surrounding clopidogrel pharmacogenetics has focused around cytochrome P450 family 2 subfamily C member 19 [CYP2C19 (pharmacokinetic)], though there is evidence for ABCB1 (pharmacokinetic), purinergic-receptor P2Y12 [P2RY12(pharmacodynamic)], cytochrome P450 family 2 subfamily C member 9 [CYP2C9 (pharmacokinetic)], and carboxylesterase 1 [CES1 (pharmacokinetic)] on drug response, which will not be discussed here.
Results: The results showed the patients with CC and CT genotype of ABCB1 C3435T had significantly higher incidence of nausea and vomiting (p<0.
By contrast, ABCB1 expression is low in the initial parts of the intestine, but higher in the ileum and colon.
CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population.
Herein, the isolation of another jatrophane (5) is presented, being the broader goal of this work to investigate the role of euphowelwitschines A (1) and B (2), welwitschene (3), epoxywelwitschene (4) and esulatin M (5) as ABCB1 modulators and/or collateral sensitivity agents.
Specific ABCB1 variants and DRD2 genetic polymorphisms (simultaneous occurrence of [greater than or equal to] 2 genetically determined phenotypes) might determine the dosage requirements of methadone.
Por ejemplo, se ha reportado que la hipermetilacion de CDKN2A es un evento que ocurre muy temprano (fase premaligna); mientras que la metilacion de los genes RASSF1A, APC, ESR1, ABCB1, MT1G y HOXC9 esta asociada con NSCLC estadio I.
The objective is to detect ABCB1 gene variants in patients who are cured with antidepressants in order to increase the efficacy of depression therapy.