ABCB1

ABCB1

A gene on chromosome 7p21.12, which encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane protein. It is an ATP-dependent efflux pump for xenobiotics with broad substrate specificity, and functions as a transporter in the blood-brain barrier.

Molecular pathology
The ABCB1 protein product is responsible for reducing drug loads in multi-drug-resistant cells, thereby mediating resistance to anti-cancer drugs.

ABCB1

Member 1 of the B subfamily of ABC TRANSPORTER PROTEINS. Also known as MDR1. Polymorphism of the gene for ABCB1 is associated with multi-drug resistance in the treatment of a range of diseases including epilepsy, various cancers, rheumatoid arthritis and inflammatory bowel disease. Clinical experience has shown that several drugs used to treat cancer may become ineffective simultaneously in spite of having unrelated chemical structure. This multi-drug resistance was shown to be due to enhanced expression of ABCB1 which was using ATP-derived energy to export drugs from the cytosol to the extracellular fluid.
References in periodicals archive ?
We can finally conclude that in this population the response of individuals to ondansetron seems to be affected by ABCB1 gene C3435T polymorphism.
Specific ABCB1 variants and DRD2 genetic polymorphisms (simultaneous occurrence of [greater than or equal to] 2 genetically determined phenotypes) might determine the dosage requirements of methadone.
Results: Among the tested ABC efflux transporters, [beta]-carotene significantly inhibited human P-gp efflux function without altering ABCB1 mRNA expression.
P-glycoprotein (P-gp) is an efflux transporter encoded by the ABCB1 (also known as MDR1) gene that protects the brain against neurotoxicants [66].
Cyclosporine and tacrolimus (CNI) are known to be a substrate of cytochrome P450 (CYP) 3A5 and P-glycoprotein (P-gp), which are encoded by CYP3A5 gene and ATP-binding cassette subfamily B member 1 (ABCB1) gene, also known as multidrug-resistant gene 1 (MDR1), respectively (15,16,17,18).
Genotyping analyses of ABCB1 C3435T ABCG2 C421A and ABCC3 C-211T were conducted using the TaqMan methodology.
Of the 49 human ABC transporters, 15 are implicated in conferring resistance to chemotherapeutic agents in various cancers, and the most intensively characterized members are multidrug resistance 1 (MDR1 or P-glycoprotein, ABCB1), multidrug resistance protein 1 (MRP1, ABCC1), and breast cancer resistance protein (BCRP, ABCG2) [7].
Impact of genetic polymorphisms in ABCB1, CYP2B6, OPRM1, ANKK1 and DRD2 genes on methadone therapy in Han Chinese patients.
Ieiri, "Functional significance of genetic polymorphisms in P-glycoprotein (MDR1, ABCB1) and breast cancer resistance protein (BCRP, ABCG2)," Drug Metabolism and Pharmacokinetics, vol.
ABC transporter BBB BSCB Localization in (gene) brain capillary endothelium P-gp (ABCB1) Yes [24] Yes[35] Luminal [25] MRP1 (ABCC1) Yes [24, 25, 40] Yes[40] Luminal [25] Abluminal [24] MRP2 (ABCC2) Yes [24, 27] Yes[35] Luminal [25] MRP3 (ABCC3) Yes [24] ?
Is a key transporter in the disposition of drugs in the CNS, some polymorphisms of ABCB1 gene, which encodes P-gp, produce a poor transporter that modifies the distribution of psychoactive drugs in the CNS and other tissues (8) ; (g) CYP2B6 enzyme.
2008), both phase II DME genes; ABCB1 [ATP-binding cassette, subfamily B, member 1; also named multidrug resistance 1 (MDR1)] (Tang et al.