ABCB1, ATP-binding cassette sub-family B member 1; TP, adenosine triphosphate; CNS, central nervous system; CYP, cytochrome P450 enzyme; OCT2, organic cation transporter 2; PPIs, proton pump inhibitors.
Role of the multidrug transporter proteins
ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta.
Concise review: clinical relevance of drug-drug and herb-drug interactions mediated by the ABC transporter
ABCB1 (MDR1, P-glycoprotein).
They identified significant associations of childhood all risk with haplotypes of
ABCB1, ARNT, CYP2C8, CYP1A2, CYP1B1, AND IDHI.
The majority of the evidence surrounding clopidogrel pharmacogenetics has focused around cytochrome P450 family 2 subfamily C member 19 [CYP2C19 (pharmacokinetic)], though there is evidence for
ABCB1 (pharmacokinetic), purinergic-receptor P2Y12 [P2RY12(pharmacodynamic)], cytochrome P450 family 2 subfamily C member 9 [CYP2C9 (pharmacokinetic)], and carboxylesterase 1 [CES1 (pharmacokinetic)] on drug response, which will not be discussed here.
Results: The results showed the patients with CC and CT genotype of
ABCB1 C3435T had significantly higher incidence of nausea and vomiting (p<0.
By contrast,
ABCB1 expression is low in the initial parts of the intestine, but higher in the ileum and colon.
CYP2C19 and
ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population.
Herein, the isolation of another jatrophane (5) is presented, being the broader goal of this work to investigate the role of euphowelwitschines A (1) and B (2), welwitschene (3), epoxywelwitschene (4) and esulatin M (5) as
ABCB1 modulators and/or collateral sensitivity agents.
Specific
ABCB1 variants and DRD2 genetic polymorphisms (simultaneous occurrence of [greater than or equal to] 2 genetically determined phenotypes) might determine the dosage requirements of methadone.
Por ejemplo, se ha reportado que la hipermetilacion de CDKN2A es un evento que ocurre muy temprano (fase premaligna); mientras que la metilacion de los genes RASSF1A, APC, ESR1,
ABCB1, MT1G y HOXC9 esta asociada con NSCLC estadio I.
The objective is to detect
ABCB1 gene variants in patients who are cured with antidepressants in order to increase the efficacy of depression therapy.
