ABCA1


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ABCA1

ATP-binding cassette transporter ABCA1. A protein encoded by ABCA1 on chromosome 9p31, which is a major regulator in transporting cholesterol and phospholipids out of cells that later bind with ApoA1 in the circulation.
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Since high levels of HDL-c are atheroprotective, there is extensive interest in developing agents that enhance ABCA1 expression and thereby raise plasma HDL-c levels.
It has been reported that the production of apoE/HDL in the CNS also depends on ABCA1 [48-51].
The genotype distribution of ABCA1 C-565T polymorphism was in accordance with the Hardy-Weinberg equilibrium in both CAD patients (p = 0.625) and control subjects (p = 0.340).
In addition, SREBPs suppress expression of ABCA1 that removes cholesterol to extracellular acceptors.
We found that RM-1-conditioned medium induced LXR[alpha] activation with increasing the expression of the LXR target genes ABCG1 and ABCA1. However, PG[E.sub.2] reversed this activation with decreasing ABCG1 and ABCA1 expression and further expression of LXR[alpha] (Figure 1).
Moreover, studies have demonstrated that niacin increases PPAR expression, through macrophage ABCA1, which affects reverse cholesterol transport [139].
We searched EMBASE, PubMed, and Web of Science using the following MeSH terms and free words: (polypoidal choroidal vasculopathy or polypoidal choroidal vascular disease or polypoidal choroidal vascular diseases or PCV) and (cholesteryl ester transfer protein or CETP or hepatic lipase or LIPC or lipoprotein lipase or LPL or ATP-binding cassette transporter A1 or ABCA1 or ATP-binding cassette transporter G1 or ABCG1).
Recent studies showed that LXR[alpha] is considered as a critical regulator in cholesterol homeostasis in macrophages, which could regulate several genes involved in cholesterol transport, such as the ATP-binding cassette trans-porters (ABCs), ABCA1, ABCG1, apolipoprotein E (ApoE) and lipoprotein lipase (LPL) (Vinoda et al., 2014).
The RCT process is mainly performed by two crucial cellular factors, transporter (ATP-binding cassette transporter member A1 (ABCA1) and receptor (scavenger receptor class B type I (SR-BI)).
Para la formacion de las HDL, la Apo-AI es secretada principalmente por el higado y el intestino delgado en forma libre, (figura 2) y rapidamente obtiene pequenas cantidades de fosfolipidos a traves de la proteina transportadora dependiente de ATP 1 (ABCA1), incrementando el contenido lipidico y formando lo que se conoce como HDL pre-p migrante o HDL naciente (15).
The most likely mechanism explaining the beneficial effects of elevated serum apoA-I concentrations origins from the fact that apoA-I is the ligand for ATP-binding cassette transporter A1 (ABCA1), as such mediating cholesterol efflux from lipid-laden macrophages [8].
In this study, they found that vitamin E was able to show this protective effect through decreased expression of matrix metalloproteinase-1 (MMP-1) and increased expression of PPAR[gamma], GST-a, and ATP-binding cassette transporter 1 (ABCA1) in the aortae of cholesterol-fed rabbits [94].