ABCA1


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ABCA1

ATP-binding cassette transporter ABCA1. A protein encoded by ABCA1 on chromosome 9p31, which is a major regulator in transporting cholesterol and phospholipids out of cells that later bind with ApoA1 in the circulation.
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Besides, peroxisome proliferator-activatedreceptor-alpha (PPAR[alpha]) can activate the cytochrome p450 enzymes, resulting in some of the hydroxyl cholesterol as LXR[alpha] endogenous ligand further activate LXR[alpha], which further activating ABCA1 regulated cholesterol efflux.
10) This process involves two main factors, namely ABCA1 and SR-BI.
Esta patologia se debe a una deficiencia de la proteina ABCA1 (86), la cual es critica en la formacion de las nuevas particulas de HDL.
Free cholesterol is the form of cholesterol effluxed to nascent HDL by ABCA1 (65).
Deleting the ABCA1 gene in young macrophages caused them to behave like old macrophages.
Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway.
If ABCA1 function is lost in cancer cells, cholesterol builds up in the cells' mitochondria, making their membranes more rigid.
HDL interacts with a receptor called ABCA1 on various cells, causing the release (i.
Association study between cholesterol metabolism genes (APOE, ABCA1 and VDR) and sporadic Alzheimer's disease [master's thesis].
Also, additional data from the literature indicating unaltered ABCA1 expression, another member of ATP dependent MRPs family in cholesterol loaded cytoresistant tubule cells (Zager et al.
Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels.