It has been reported that different cell types have characteristic expression patterns of ABC transporters which depend on the cell's maturation state, further supporting the idea that multiple ABC transporter proteins may facilitate the pluripotency of the stem cell population [20, 27].
Following the observation that the SP is usually lost after cells are treated with verapamil, a [Ca.sup.+] channel and known Pgp blocker, it was assumed that the ABC transporter protein P-gp is responsible for Hoechst dye efflux [13, 24, 32].
Locher, "Structure and mechanism of ABC transporter proteins
," Current Opinion in Structural Biology, vol.
This indicates that the reversing mechanism of paeonol on paclitaxel resistance in breast cancer could be associated with the reduction in the expression of transgelin 2-mediated ABC transporter proteins.
The role of the ABC transporter proteins P-gp, MRPl, and BCRP in MCF-7/PTX cells was investigated simultaneously in the present study.
ABC transporter proteins
act as cellular gatekeepers by retaining nutrients and expelling toxins from the cell.