ABC transporter proteins

ABC transporter proteins

a superfamily of carrier proteins that bind two highly conserved ATP-binding cassettes and function in transporting peptides, sugars, polysaccharides, and ions across the cell membrane. Mutations in the gene that codes for one of these ABC transporter proteins is believed to be responsible for cystic fibrosis.
See also: cystic fibrosis, carrier protein.
[ATP-binding cassette]

ABC transporter proteins

A large and diverse family of cell membrane transport proteins with two transmembrane domains and two ATP-binding regions within the cytosol. The transmembrane domains provide a controllable pathway for transported substance to pass through the cell membrane into or out of the cell.
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It has been reported that different cell types have characteristic expression patterns of ABC transporters which depend on the cell's maturation state, further supporting the idea that multiple ABC transporter proteins may facilitate the pluripotency of the stem cell population [20, 27].
Following the observation that the SP is usually lost after cells are treated with verapamil, a [Ca.sup.+] channel and known Pgp blocker, it was assumed that the ABC transporter protein P-gp is responsible for Hoechst dye efflux [13, 24, 32].
Locher, "Structure and mechanism of ABC transporter proteins," Current Opinion in Structural Biology, vol.
This indicates that the reversing mechanism of paeonol on paclitaxel resistance in breast cancer could be associated with the reduction in the expression of transgelin 2-mediated ABC transporter proteins.
The role of the ABC transporter proteins P-gp, MRPl, and BCRP in MCF-7/PTX cells was investigated simultaneously in the present study.
ABC transporter proteins act as cellular gatekeepers by retaining nutrients and expelling toxins from the cell.