TAP2(redirected from ABC transporter, MHC 2)
TAP2A gene on chromosome 6p21.3 that encodes a member of the MDR/TAP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which plays a role in multidrug resistance and antigen presentation. TAP2 forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum.
TAP2 mutations have been tentatively linked to ankylosing spondylitis, type-1 diabetes and coeliac disease.
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